신진과학자 소개

이 상 미 (Sangmi Lee)

충북대학교 식품영양학과 E-mail : sangmilee@chungbuk.ac.kr

주요 연구 관심 분야 소개

• 다양한 오염원에서 식중독균의 분포 규명
• 비교유전체학을 이용한 식중독균의 유전적 다양성 연구
• 식중독균의 유전자 기능 및 조절기작 연구
• Biocontrol agent를 이용한 식중독균 제어법 개발
• 식중독균 신속검출법 개발

연구성과 - 논문

• Parsons, C.*, Lee, S.*, and S. Kathariou. 2019. Heavy metal resistance determinants of the foodborne pathogen Listeria monocytogenes. Genes. 10:11.

* Authors contributed equally to this manuscript.

• 1. Lee, S., Y. Chen, L. Gorski, T. J. Ward, J. Osborne, and S. Kathariou. 2018. Listeria monocytogenes source distribution analysis indicates regional heterogeneity and ecological niche preference among serotype 4b clones. mBio. 9:e00396-18.
• 2. Lee, S., D. E. A. Lewis, and S. Adhya. 2018. The developmental switch in bacteriophage λ: a critical role of the Cro protein. J. Mol. Biol. 430:58-68.
• 3. Lee, S., T. J. Ward, D. D. Jima, C. Parsons, and S. Kathariou. 2017. The arsenic resistance-associated Listeria genomic island LGI2 exhibits sequence and integration site diversity and a propensity for three Listeria monocytogenes clones with enhanced virulence. Appl. Environ. Microbiol. 83:e01189-17.
• 4. Dutta, V., S. Lee, T. J. Ward, N. Orwig, E. Altermann, D. D. Jima, C. Parsons, and S. Kathariou. 2017. Genome sequences of Listeria monocytogenes strains with resistance to arsenic. Genome Announc. 5:e00327-17.
• 5. Parsons, C., S. Lee, V. Jayeola, and S. Kathariou. 2017. Novel cadmium resistance determinant in Listeria monocytogenes. Appl. Environ. Microbiol. 83:e02580-16.
• 6. Dutta, V., S. Lee, T. J. Ward, N. Orwig, E. Altermann, D. Jima, C. Parsons, and S. Kathariou. 2016. Draft genome sequences of two historical Listeria monocytogenes strains from human listeriosis cases in 1933. Genome Announc. 4:e01364-16.
• 7. Wallace, J. W., W. L. Nicholson, J. L. Perniciaro, M. F. Vaughn, S. Funkhouser, J. J. Juliano, S. Lee, M. L. Kakumanu, L. Ponnusamy, C. S. Apperson, and S. R. Meshnick. 2016. Incident tick-borne infections in a cohort of North Carolina outdoor workers. Vector Borne Zoonotic Dis. 16:302-308.
• 8. Lee, S., M. L. Kakumanu, L. Ponnusamy, M. Vaughn, S. Funkhouser, H. Thornton, S. R. Meshnick, and C. S. Apperson. 2014. Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina. Parasites & Vectors 7:607.
• 9. Lee, S., T. J. Ward, L. M. Graves, C. L. Tarr, R. M. Siletzky, and S. Kathariou. 2014. Population structure of Listeria monocytogenes serotype 4b isolates from sporadic human listeriosis in the United States, 2003–2008. Appl. Environ. Microbiol. 80:3632-3644.
• 10. Lee, S., M. Rakic-Martinez, L. M. Graves, T. J. Ward, R. M. Siletzky, and S. Kathariou. 2013. Genetic determinants for cadmium and arsenic resistance among Listeria monocytogenes serotype 4b isolates from sporadic human listeriosis patients. Appl. Environ. Microbiol. 79:2471-2476.
• 11. Kim, J., V. Dutta, D. Elhanafi, S. Lee, J. A. Osborne, and S. Kathariou. 2012. A novel restriction-modification system is responsible for temperature-dependent phage resistance in Listeria monocytogenes ECII. Appl. Environ. Microbiol. 78:1995-2004.
• 12. Lee, S., T. J. Ward, R. M. Siletzky, and S. Kathariou. 2012. Two novel type II restriction-modification systems occupying genomically equivalent locations on the chromosomes of Listeria monocytogenes strains. Appl. Environ. Microbiol. 78:2623-2630.
• 13. Lee, S., T. J. Ward, L. M. Graves, L. A. Wolf, K. Sperry, R. M. Siletzky, and S. Kathariou. 2012. Atypical Listeria monocytogenes serotype 4b strains harboring a lineage II-specific gene cassette. Appl. Environ. Microbiol. 78:660-667.
• 14. Cheng, Y., J. W. Kim, S. Lee, R. M. Siletzky, and S. Kathariou. 2010. DNA probes for unambiguous identification of Listeria monocytogenes Epidemic Clone II strains. Appl. Environ. Microbiol. 76:3061-3068.
• 15. Shin, D., S. Lee, Y. Shin, and S. Ryu. 2006. Identification of a novel genetic locus affecting ptsG expression in Escherichia coli. J. Microbiol. Biotechnol. 16:795-798.

연구성과 - 저서 (북챕터)

• 1. Lee, S., R. M. Siletzky, and S. Kathariou. 2012. Epidemiology, pathogenesis, ecology and genetics of Listeria monocytogenes, p. 251-268. In S. Faruque (ed.), Foodborne and waterborne bacterial pathogens: epidemiology, evolution and molecular biology, 1st ed. Caister Academic Press, Norfolk, UK.