1. Han S*, Cha GS*, Chun YJ, Lee CH, Kim D, Yun CH. Biochemical analysis of recombinant CYP4A11 allelic variant enzymes: W126R, K276T and S353G. Drug Metab Pharmacokinet. 2016 Dec;31(6):445-450.
*These authors are equally contributed in this paper
2. Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D. Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue. Mol Cells. 2016 Mar;39(3):211-6
3. Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D. Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A. Arch Biochem Biophys. 2015 Jun 1;575:1-7
4. Park JH*, Lee SH*, Cha GS*, Choi DS, Nam DH, Lee JH, Lee JK, Yun CH, Jeong KJ, Park CB. Cofactor-free light-driven whole-cell cytochrome P450 catalysis. Angew Chem Int Ed Engl. 2015 Jan 12;54(3):969-73.
*These authors are equally contributed in this paper
5. Kim D*, Cha GS*, Nagy LD, Yun CH, Guengerich FP. Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. Biochemistry. 2014 Oct 7;53(39):6161-72.
*These authors are equally contributed in this paper
6. Cha GS, Ryu SH, Ahn T, Yun CH. Regioselective hydroxylation of 17β-estradiol by mutants of CYP102A1 from Bacillus megaterium. Biotechnol Lett. 2014 Dec;36(12):2501-6.
7. Kang JY, Ryu SH, Park SH, Cha GS, Kim DH, Kim KH, Hong AW, Ahn T, Pan JG, Joung YH, Kang HS, Yun CH. Chimeric cytochromes P450 engineered by domain swapping and random mutagenesis for producing human metabolites of drugs. Biotechnol Bioeng. 2014 Jul;111(7):1313-22.
연구성과 - 특허
1. 박테리아 시토크롬 P450을 이용한 17베타-에스트라다이올로부터 대사산물의 생산방법 및 이를 위한 조성물
윤철호, 박선하, 차건수, 류상훈, 국내특허등록
2. 아스트린진 제조용 신규한 조성물
윤철호, 강형식, 정영희, 차건수, 국내특허등록
3. 내당성이 높은 락토바실러스 플랜타룸 WiKim0067 및 이를 이용한 발효식품
홍성욱, 이종희, 차건수, 최현우, 황혜련, 국내특허등록
4. Composition for astringin product
윤철호, 강형식, 정영희, 차건수, 해외특허등록(미국)