신진과학자 소개

안 홍 찬 (Hongchan An)

대구경북첨단의료산업진흥재단 신약개발지원센터 E-mail : hongchanan@dgmif.re.kr

주요 연구 관심 분야 소개

• Medicinal chemistry for metabolic disorders and angiogenesis-related diseases including cancer and ocular diseases.
• Development of DNA-compatible reactions on beads for solid-phase DNA-encoded libraries.

연구성과 - 논문

• 1. Novel hypoxia-inducible factor 1α (HIF-1α) inhibitors for angiogenesis-related ocular diseases: Discovery of a novel scaffold via ring-truncation strategy. H. An; S. Lee; J. M. Lee; D. H. Jo; J. Kim; Y.-S. Jeong; M. J. Heo; C. S. Cho; H. Choi; J. H. Seo; S. Hwang; J. Lim; T. Kim; H. O. Jun; J. Sim; C. Lim; J. Hur; J. Ahn; H. S. Kim; S.-Y. Seo; Y. Na; S.-H. Kim; J. Lee; J. Lee; S.-J. Chung; Y.-M. Kim; K.-W. Kim; S. G. Kim; J. H. Kim and Y.-G. Suh, J. Med. Chem. 2018, 61, 9266-9286.
• 2. Conformation-enabled total syntheses of ohmyungsamycins A and B and structural revision of ohmyungsamycin B. J. Hur; J. Jang; J. Sim; W. S. Son; H.-C. Ahn; T. S. Kim; Y.-H. Shin; C. Lim; S. Lee; H. An; S.-H. Kim; D.-C. Oh; E.-K. Jo; J. Jang; J. Lee and Y.-G. Suh, Angew. Chem. Int. Ed. 2018, 57, 3069-3073.
• 3. Stereoselective synthesis of 1,4,5-tri-cis-guaiane sesquiterpene: First total synthesis of (−)-dendroside C aglycon. J. Sim; H. Park; J. Lim; I. Yoon; C. Lim; H. An; H. Yun; H. J. Choi and Y.-G. Suh, Org. Lett. 2018, 20, 586-589
• 4. Asymmetric total synthesis of (+)-(3E)-pinnatifidenyne via abnormally regioselective Pd(0)-catalyzed endocyclization. H. S. Kim; T. Kim; J. Ahn; H. Yun; C. Lim; J. Jang; J. Sim; H. An; Y.-J. Surh; J. Lee and Y.-G. Suh, J. Org. Chem. 2018, 83, 1997-2005
• 5. DNA-compatible solid-phase combinatorial synthesis of β-cyanoacrylamides and related electrophiles. K. Pels; P. Dickson; H. An and T. Kodadek, ACS Comb. Sci. 2018, 20, 61-69.
• 6. Total synthesis of (+)-brasilenyne via concise construction of an oxonane framework containing a 1,3-cis,cis-diene. C. Lim; J. Ahn; J. Sim; H. Yun; J. Hur; H. An; J. Jang; S. Lee and Y.-G. Suh, Chem. Commun. 2018, 54, 467-470.
• 7. Asymmetric total synthesis of (+)-Intricenyne via an endocyclization route to oxocane skeleton. J. Ahn; C. Lim; H. Yun; H. S. Kim; S. Kwon; J. Lee; S. Lee; H. An; H.-g. Park and Y.-G. Suh, Org. Lett. 2017, 19, 6642-6645.
• 8. Asymmetric synthesis of vinylogous beta-amino acids and their incorporation into mixed backbone oligomers. H. Wu^#; H. An#; S. Mo and T. Kodadek, Org. Biomol. Chem. 2017, 15, 3255-3264. (# Equal contribution)
• 9. Identification and structural analysis of new Nrf2 activators by mechanism-based chemical transformation of 15-Deoxy-∆12, 14 -PGJ₂. K. Kim; J.-M. Park; N.-J. Kim; S.-J. Kim; H. Moon; H. An; J. Lee; H.-J. Park; Y.-J. Surh and Y.-G. Suh, ChemBioChem 2016, 17, 1900-1904.
• 10. Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism. J. Lee; S. Lee; S. Chung; N. Park; G. H. Son; H. An; J. Jang; D.-J. Chang; Y.-G. Suh and K. Kim, Biochem. Biophys. Res. Commun. 2016, 469, 580-586.
• 11. Deguelin analogue SH-1242 inhibits Hsp90 activity and exerts potent anticancer efficacy with limited neurotoxicity. S.-C. Lee; H.-Y. Min; H. Choi; S. Y. Bae; K. H. Park; S. Y. Hyun; H. J. Lee; J. Moon; S.-H. Park; J. Y. Kim; H. An; S.-J. Park; J. H. Seo; S. Lee; Y.-M. Kim; H.-J. Park; S. K. Lee; J. Lee; J. Lee; K.-W. Kim; Y.-G. Suh and H.-Y. Lee, Cancer Res. 2016, 76, 686-699.
• 12. Divergent synthetic route to new cyclopenta[c]pyran iridoids: Syntheses of jatamanin A, F, G and J, gastrolactone and nepetalactone. J. Sim; I. Yoon; H. Yun; H. An and Y.-G. Suh, Org. Biomol. Chem. 2016, 14, 1244-1251.
• 13. Diastereoselective total synthesis of (-)-galiellalactone. T. Kim; Y. T. Han; H. An; K. Kim; J. Lee and Y.-G. Suh, J. Org. Chem. 2015, 80, 12193-12200.
• 14. Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action. K. Kim; S.-J. Kim; Y. T. Han; S.-J. Hong; H. An; D.-J. Chang; T. Kim; B. Lim; J. Lee; Y.-J. Surh and Y.-G. Suh, Bioorg. Med. Chem. Lett. 2015, 25, 5444-5448.
• 15. Synthesis and biological evaluation of novel homoisoflavonoids for retinal neovascularization. H. D. Basavarajappa; B. Lee; H. Lee; R. S. Sulaiman; H. An; C. Magana; M. Shadmand; A. Vayl; G. Rajashekhar; E.-Y. Kim; Y.-G. Suh; K. Lee; S.-Y. Seo and T. W. Corson, J. Med. Chem. 2015, 58, 5015-5027.
• 16. Total synthesis of (-)-deguelin via an iterative pyran-ring formation strategy. S. Lee; H. An; D.-J. Chang; J. Jang; K. Kim; J. Sim; J. Lee and Y.-G. Suh, Chem. Commun. 2015, 51, 9026-9029.
• 17. Synthesis and synthesis-based structural elucidation of (‒)-Macrosphelides J and K. H. An; S.-H. Kim; H. Kim; K. Kim; J. Sim; J. Jang; S.-M. Paek; Y.-G. Suh and H. Yun, Heterocycles 2015, 91, 970-988.
• 18. Fine tuning of 4,6-bisphenyl-2-(3-alkoxyanilino)pyrimidine focusing on the activity-sensitive aminoalkoxy moiety for a therapeutically useful inhibitor of receptor for advanced glycation end products (RAGE). Y. T. Han; K. Kim; D. Son; H. An; H. Kim; J. Lee; H.-J. Park; J. Lee and Y.-G. Suh, Bioorg. Med. Chem. 2015, 23, 579-587.
• 19. Efficient strategy for the stereoselective synthesis of 2,3-disubstituted benzo[α]quinolizidine alkaloids: concise synthesis of (−)-protoemetinol. H. Moon; H. An; J. Sim; K. Kim; S.-M. Paek and Y.-G. Suh, Tetrahedron Lett. 2015, 56, 608-611.
• 20. Design and synthesis of a macrosphelide A-biotin chimera. H. Yun; J. Sim; H. An; J. Lee; H. S. Lee; Y. K. Shin; S.-M. Paek and Y.-G. Suh, Org. Biomol. Chem. 2014, 12, 7127-7135.
• 21. Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors. D. H. Jo; H. An; D.-J. Chang; Y.-Y. Baek; C. S. Cho; H. O. Jun; S.-J. Park; J. H. Kim; H.-Y. Lee; K.-W. Kim; J. Lee; H.-J. Park; Y.-M. Kim; Y.-G. Suh and J. H. Kim, J. Mol. Med. 2014, 92, 1083-1092.
• 22. Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE). Y. T. Han; K. Kim; G.-I. Choi; H. An; D. Son; H. Kim; H.-J. Ha; J.-H. Son; S.-J. Chung; H.-J. Park; J. Lee and Y.-G. Suh, Eur. J. Med. Chem. 2014, 79, 128-142.
• 23. Glucal-conjugated sterols as novel vascular leakage blocker: Structure–activity relationship focusing on the C17-side chain. K. Kim; S. Maharjan; C. Lim; N.-J. Kim; V. Agrawal; Y. T. Han; S. Lee; H. An; H. Yun; H.-J. Choi; Y.-G. Kwon and Y.-G. Suh, Eur. J. Med. Chem. 2014, 75, 184-194.
• 24. Microwave-assisted synthesis of 3-substituted indoles via intramolecular arene–alkene coupling of o-iodoanilino enamines. W.-I. Lee; J.-W. Jung; J. Sim; H. An and Y.-G. Suh, Tetrahedron 2013, 69, 7211-7219.
• 25. Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. D.-J. Chang; H. An; K.-s. Kim; H. H. Kim; J. Jung; J. M. Lee; N.-J. Kim; Y. T. Han; H. Yun; S. Lee; G. Lee; S. Lee; J. S. Lee; J.-H. Cha; J.-H. Park; J. W. Park; S.-C. Lee; S. G. Kim; J. H. Kim; H.-Y. Lee; K.-W. Kim and Y.-G. Suh, J. Med. Chem. 2012, 55, 10863-10884.
• 26. Design, synthesis and insight into the structure–activity relationship of 1, 3-disubstituted indazoles as novel HIF-1 inhibitors. H. An; N.-J. Kim; J.-W. Jung; H. Jang; J.-W. Park and Y.-G. Suh, Bioorg. Med. Chem. Lett. 2011, 21, 6297-6300.
• 27. Design, synthesis and identification of novel colchicine-derived immunosuppressant. D.-J. Chang; E.-Y. Yoon; G.-B. Lee; S.-O. Kim; W.-J. Kim; Y.-M. Kim; J.-W. Jung; H. An and Y.-G. Suh, Bioorg. Med. Chem. Lett. 2009, 19, 4416-4420.

연구성과 - 특허

• 1. Novel compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient. Y.-G. Suh; D.-J. Chang; H. An; K.-W. Kim; Y.-M. Kim and H.-Y. Lee, European Patent No. 2,871,187 B1, SNU R&DB Foundation, 2017.
• 2. Compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient. Y.-G. Suh; H. An; S. Lee; K.-W. Kim; H.-Y. Lee; S. G. Kim and J. H. Kim, United States Patent No. 9,745,280 B2, SNU R&DB Foundation, 2017.
• 3. 서영거; 장동조; 안홍찬; 김규원, 신규한 데구엘린 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약학적 조성물, 대한민국 특허 등록번호 10-1414722, 등록일자 2014년 6월 26일.
• 서영거; 장동조; 안홍찬; 김규원, 신규한 데구엘린 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약학적 조성물, 대한민국 특허 등록번호 10-1269097, 등록일자 2013년 5월 23일.