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2019 May Vol.32 No.3 ISSN 1598-8384

신진과학자

신진과학자 소개

서승오
서승오(Seung-OhSeo, SOS)

가톨릭대학교 식품영양학전공 E-mail : drsos@catholic.ac.kr

[학력]
  • 2003.03 – 2009.08

    성균관대학교 생명공학부 식품생명공학전공, 학사 (이학사)

  • 2009.09 – 2011.08

    서울대학교 농생명공학부식품생명공학전공, 석사 (농학석사)

  • 2012.08 – 2017.05

    University of Illinois at Urbana-Champaign,Dept. of Food Science and Human Nutrition, 박사 (이학박사)

[경력]
  • 2011.09 – 2012.06

    서울대학교 농업생물신소재연구소,연구원

  • 2017.06 – 2019.01

    University of Minnesota Twin Cities,BMBB/BTI, 박사후 연구원

  • 2019.02 – 현재

    가톨릭대학교 식품영양학전공, 조교수

주요 연구 관심 분야 소개

  • 오믹스 기반의 개인 맞춤형 식품 개발
  • 장내 마이크로바이옴과프로바이오틱스 연구
  • 건강기능식품 및 식의약 소재 개발
  • 미생물공장화 기술을 이용한 유용산물 생산
  • CRISPR기술을 이용한 정밀 유전체 편집

연구성과 - 논문

  • 1. Jang, Y., Kim, S.A., Seo, S.O., Li, L., Han, N.S. Plasmid curing resulted in improved heterologous gene expression in Leuconostoc citreum EFEL2700. 2019, Letters in Applied Microbiology, 68(5):430-436.
  • 2. Seo, S.O., and Schmidt-Dannert, C. Development of a synthetic cumate-inducible gene expression system in Bacillus. 2019, Applied Microbiology and Biotechnology, 103(1): 303-313.
  • 3. Seo, S.O., Lu, T., Jin, Y.S., Blaschek, H.P. Development of an oxygen-independent flavin mononucleotide-based fluorescent reporter system in Clostridium beijerinckii and its potential applications. 2018, Journal of Biotechnology, 265: 119-126.
  • 4. Zhang, Z.T., P Jiménez-Bonilla, Seo, S.O., Lu, T., Jin, Y.S., Blaschek, H.P. Wang, Y. Bacterial genome editing with CRISPR-Cas9: Taking Clostridium beijerinckii as an example. 2018, Methods in Molecular Biology,1772: 297-325.
  • 5. Seo, S.O., Jenssen, H., Magis, A., Wang, Y., Lu, T., Price, N.D., Jin, Y.S., Blaschek, H.P. Genomic, transcriptional and phenotypic analysis of the glucose derepressed Clostridium beijerinckii mutant exhibiting acid crash phenotype. 2017, Biotechnology Journal,12(11).
  • 6. Jang, Y.*, Seo, S.O.*, Kim, S.A., Kim, T.J., Kim, S.C., Jin, Y.S., Han, N.S. Elimination of the cryptic plasmid in Leuconostoc citreum by CRISPR/Cas9 system. 2017, Journal of Biotechnology, 251: 151-155.
  • 7. Seo, S.O., Wang, Y., Lu, T., Jin, Y.S., Blaschek, H. P. Characterization of Clostridium beijerinckii spo0A mutant and its application to butyl butyrate production. 2017, Biotechnology and Bioengineering,114(1): 106-112.
  • 8. Kim, J.W., Kim, J.Y, Seo, S.O., Kim. K.H., Jin, Y.S., Seo, J.H. Enhanced production of 2,3-butanediol by engineered Saccharomyces cerevisiae through fine-tuning of pyruvate decarboxylase and NADH oxidase activities. 2016, Biotechnology for Biofuels,9: 265.
  • 9. Xia, P.F., Zhang, G.C., Walker, B., Seo, S.O., Kwak, S., Liu, J.J., Kim, H., Ort, D.R., Wang, S.G., Jin, Y.S. Recycling carbon dioxide during xylose fermentation by engineered Saccharomyces cerevisiae. 2016, ACS Synthetic Biology,6(2): 276-283.
  • 10. Choi, E.J., Kim, J.W, Kim, S.J., Seo, S.O., Lane, S., Park, Y.C., Jin, Y.S., Seo, J.H. Enhanced production of 2,3-butanediol in pyruvate decarboxylase-deficient Saccharomyces cerevisiae through optimizing ratio of glucose/galactose. 2016, Biotechnology Journal,11(11): 1424-1432.
  • 11. Wang, Y., Zhang, Z.T., Seo, S.O., Lynn, P., Lu, T., Jin, Y.S., Blaschek, H.P. Gene transcription repression in Clostridium beijerinckii using CRISPR-dCas9. 2016 Biotechnology and Bioengineering, 113(12): 2739-2743.
  • 12. Liao, C., Seo, S.O., Lu, T. System-level modeling of acetone-butanol-ethanol fermentation. 2016, FEMS Microbiology Letters, 363(9).
  • 13. Wang, Y., Zhang, Z.T., Seo, S.O., Lynn, P., Lu, T., Jin, Y.S., Blaschek, H.P. Bacterial genome editing with CRISPR-Cas9: deletion, integration, single nucleotide modification, and desirable clean mutant selection in Clostridium beijerinckii as an example. 2016, ACS Synthetic Biology,5(7): 721-732.
  • 14. Liao, C., Seo, S.O., Celik, V., Liu, H., Kong, W., Wang, Y., Blaschek, H.P., Jin, Y.S., Lu, T. An integrated, systems metabolic picture of the acetone-butanol-ethanol fermentation by Clostridium acetobutylicum. 2015, Proceedings of the National Academy of Sciences, 112(27): 8505-8510.
  • 15. Kim, J.W., Seo, S.O., Zhang, G.C., Jin, Y.S., Seo, J.H. Expression of Lactococcus lactis NADH oxidase increases 2,3-butanediol production in Pdc-deficient Saccharomyces cerevisiae. 2015, Bioresource Technology, 191: 512-519.
  • 16. Wang, Y., Zhang, Z.T., Seo, S.O., Choi, K., Lu, T., Jin, Y.S., Blascheck, H.P. Markerless chromosomal gene deletion in Clostridium beijerinckii using CRISPR/Cas9 system. 2014, Journal of Biotechnology, 200: 1-5.
  • 17. Nan, H., Seo, S.O., Oh, E.J., Seo, J.H., Cate, J.H.D., Jin, Y.S. 2,3-Butanediol production from cellobiose by engineered Saccharomyces cerevisiae. 2014, Applied Microbiology and Biotechnology, 98(12): 5757-5764.
  • 18. Kim, S.J., Seo, S.O., Park, Y.C., Jin, Y.S., Seo, J.H. Production of 2,3-butanediol from xylose by engineered Saccharomyces cerevisiae. 2014, Journal of Biotechnology, 192: 376-382.
  • 19. Kim, S.J.*, Seo, S.O.*, Jin, Y.S., Seo, J.H. Production of 2,3-butanediol by engineered Saccharomyces cerevisiae. 2013, Bioresource Technology, 146: 274-281.
  • 20. Lee, W.H.*, Seo, S.O.*, Bae, Y.H., Nan, H., Jin, Y.S., Seo, J.H. Isobutanol production in engineered Saccharomyces cerevisiae by overexpression of 2-ketoisovalerate decarboxylase and valine biosynthetic enzymes. 2012, Bioprocess and Biosystems Engineering, 35(9): 1467-1475. (*Denotes equal contribution)

연구성과 - 특허

  • 1. Seo, J.H., Kim, S.J., Seo, S.O. Method of producing 2, 3-butanediol using recombinant yeast.
    [US Patent No.: 9,328,358B2, Date of Patent: 2016. 05. 03]
  • 2. 서진호, 김수정,서승오.재조합 효모를 이용한 2,3-부탄다이올의 생산방법.
    [한국특허청등록번호:제10-1590993, 등록일: 2016. 01.27]
차세대바이오매스연구단 CJ제일제당 쎌바이오텍 대상 다인바이오 미생물유전체사업단 A3 Foresight Network 대성그룹 기산바이오 마크로젠
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