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2024 September Vol.37 No.3 ISSN 1598-8384

신진과학자

신진과학자 소개

손 현 철 (Hyeoncheol Francis Son)

전남대학교 생명과학기술학부 E-mail : hfrancis@jnu.ac.kr


[학 력]
  • 2009.03 ~ 2014.02 경북대학교 생명과학부, 학사
  • 2014.03 ~ 2019.02 경북대학교 생명과학부, 박사 (석박사통합)
[경 력]
  • 2021.01 ~ 2021.12 경북대학교 미생물연구소, 박사후연구원
  • 2022.01 ~ 2024.02 한국과학기술연구원 청정에너지연구센터, 박사후연구원
  • 2024.03 ~ 현재 전남대학교 생명과학기술학부, 조교수

주요 연구 관심 분야 소개

  • 플라스틱 분해 효소 개량
  • 미생물 기반 고부가 물질 생산성 개선을 위한 효소 개량
  • 비모델 효모 균주를 이용한 피토케미컬 생산

연구성과 – 주요논문(* Represents Co-first Author)

  • Structure-based functional analysis of a novel NADPH-producing glyceraldehyde-3-phosphate dehydrogenase from Corynebacterium glutamicum. Son H. F., Lee D., Kim S., Kim I. K., and Kim K. J. (2024) International Journal of Biological Macromolecules 255:128103
  • Highly efficient site-specific protein modification using tyrosinase from Streptomyces avermitilis: Structural insight. Hong H., Lee U. J., Lee S. H., Kim H., Lim G. M., Lee S. H., Son H. F., Kim B. G., and Kim K. J. (2024) International Journal of Biological Macromolecules 255:128313
  • Structure-guided protein engineering of glyceraldehyde-3-phosphate dehydrogenase from Corynebacterium glutamicum for dual NAD/NADP cofactor specificity. Son H. F., Yu H., Lee D., Kim I. K., and Kim K. J. (2023) Journal of Agricultural and Food Chemistry 71:17852-19859
  • Hexanoic acid improves the production of lipid and oleic acid in Yarrowia lipolytica: the benefit of integrating biorefinery with organic waste management. Choi Y. H.*, Son H. F.*, Hwang S., Kim J., Ko J. K., Gong G., Ahn J. H., Um Y., Han S. O., and Lee S. M. (2023) Environmental Technology & Innovation 31:103168
  • Crystal structure of multi-functional enzyme FadB from Cupriavidus necator: Non-formation of FadAB complex. Son H. F.*, Ahn J. W.*, Hong J., Seok J., Jin K. S., and Kim K. J. (2022) Archives of Biochemistry and Biophysics 7:109391
  • Improving lipid production of Yarrowia lipolytica by the aldehyde dehydrogenase-mediated furfural detoxification. Kim J., Son H. F., Hwang S., Gong G., Ko J. K., Um Y., Han S. O., and Lee S. M. (2022) International Journal of Molecular Sciences 23(9):4761
  • Structure based protein engineering of aldehyde dehydrogenase from Azospirillum brasilense to enhance enzyme activity against unnatural 3-hydroxypropionaldehyde. Son H. F. and Kim K. J. (2022) Journal of Microbiology and Biotechnology 32(2):1-6
  • Structure and functional characterization of bi-functional N-(5´-phosphoribosyl)anthranilate isomerase:indole-3-glycerol-phosphate synthase from Corynebacterium glutamicum. Park W. J.*, Son H. F.*, Lee D, Kim I. K., and Kim K. J. (2021) Crystal Journal of Agricultural and Food Chemistry 69:12485-12493
  • Implications for the PET decomposition mechanism through similarity and dissimilarity between PETases from Rhizobacter gummiphilus and Ideonella sakaiensis. Sagong H. Y., Son H. F., Seo H., Hong H., Lee D., and Kim K. J. (2021) Journal of Hazardous Materials 416:126075
  • Structural bioinformatics-based protein engineering of thermo-stable PETase from Ideonella sakaiensis, Son H. F., Joo S., Seo H., Sagong H. Y., Lee S. H., Hong H., and Kim K. J. (2020) Enzyme and Microbial Technology, 141, 109656
  • Decomposition of the PET film by MHETase using exo-PETase function. Sagong H. Y., Seo H., Pham T. M., Kim Y. H., Kim T., Son H. F., Joo S., Lee S. H., Kim S., Woo J. S., Hwang S. Y., and Kim K. J. (2020) ACS catalysis 10(8):4805-4812
  • Structure and function of bacterial malonyl-CoA reductase for carbon fixation. Son H. F., Kim S., Hong J. Y., Lee D. H., Park S. H., and Kim K. J. (2020) Environmental Microbiology 22(2):752-765
  • Rational protein engineering of thermo-stable PETase from Ideonella sakaiensis for highly efficient PET degradation. Son H. F.*, Cho I. J.*, Joo S. J.*, Seo H. G., Sagong H. Y., Lee S. Y., and Kim K. J. (2019) ACS catalysis 9(3):3519-3526
  • Structural insights into the inhibition properties of archaeal citrate synthase from Metallosphaera sedula. Lee S. H.*, Son H. F.*, and Kim K. J. (2019) Plos one 14(2):e0212807
  • Production of extracellular PETase from Ideonella sakaiensis using Sec-dependent signal peptides in E. coli. Seo H., Kim S. M., Son H. F., Sagong H. Y., Joo S., and Kim K. J. (2019) Biochemical and Biophysical Research Communications 501(1):250-255
  • Structural insight into D-xylose utilization of xylose reductase from Scheffersomyces stipitis. Son H. F., Lee S. M., and Kim K. J. (2018) Scientific reports 8:17442
  • Structural insight into high tyrosinase activity at acidic pH of tyrosinase from Burkholderia thailandensis. Son H. F.*, Lee S. H.*, Lee S. H.*, Kim H., Hong H., Lee U. J., Kim B. G., and Kim K. J. (2018) ACS catalysis 8(11):10375-10382
  • Polyhydroxyalkanoates biosynthetic machineries. Sagong H. Y., Son H. F., Choi S. Y., Lee S. Y., and Kim K. J. (2018) Trends in Biochemical Sciences 43(10):790-805
  • Crystal structure and biochemical characterization of xylose isomerase from Piromyces sp. E2. Son H. F., Lee S. M., and Kim K. J. (2018) Journal of Microbiology and Biotechnology 28(4):571-578
  • Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation, Joo S., Cho I. J., Seo H. G., Son H. F., Sagong H. Y., Shin T. J., Choi S. Y., Lee S. Y., and Kim K. J. (2018) Nature communications 9:382
  • Structural basis for substrate specificity of meso-diaminopimelic acid decarboxylase from Corynebacterium glutamicum. Son H. F., and Kim KJ (2018) Biochemical and Biophysical Research Communications 495:1815-1821
  • Structural insights into the production of 3-hydroxypropionic acid by aldehyde dehydrogenase from Azospirillum brasilense. Son H. F., Park S. H., Yoo T. H., Jung G. Y., and Kim K. J., Scientific reports 7:46005
  • Crystal structure and pyridoxal 5-phosphate binding property of lysine decarboxylase from Selenomonas ruminantium, Sagong H. Y., Son H. F., Kim S. H., Kim Y. H., Kim I. K., and Kim K. J. (2016) Plos One 11(11):e0166667
  • Structural basis for cytokinin production by LOG from Corynebacterium glutamicum, Seo H., Kim S. W., Sagong H. Y., Son H. F., Jin K. S., Kim I. K., and Kim K. J. (2016) Scientific reports 6:31390
  • Structural insights into a novel class of aspartate aminotransferase from Corynebacterium glutamicum. Son H. F. and Kim K. J. (2016) Plos one 11(6):e0158402
  • Small angle X-ray scattering studies of CTNNBL1 dimerization and CTNNBL1/CDC5L complex. Ahn J. W., Jin K. S., Son H. F., Chang J. H., and Kim K. J. (2015) Scientific reports 5:14251
  • Structural insights into domain movement and cofactor specificity of glutamate dehydrogenase from Corynebacterium glutamicum. Son H. F., Kim I. K., and Kim K. J. (2015) Biochemical and biophysical research communications 459(3):387-392
  • Cloning, expression, purification, crystallization and X-ray crystallographic analysis of beta-keto thiolase B from Ralstonia eutropha H16, Kim E. J.*, Son H. F.*, Chang J. H., and Kim K. J. (2014) Acta crystallographica section F-Structural biology and crystallization communications 70:316-319
  • Crystal structure and biochemical characterization of beta-keto thiolase B from polyhydroxyalkanoate-producing bacterium Ralstonia eutropha H16. Kim E. J.*, Son H. F.*, Kim S., Ahn J. W., and Kim K. J. (2014) Biochemical and Biophysical Research Communication, 444(3):365-369