신진과학자 소개

안 정 호 (Jung Ho Ahn)

한국과학기술연구원 청정에너지연구센터 E-mail : ajungho@kist.re.kr

주요 연구 관심 분야 소개

• 시스템대사공학 기반 유용화학소재 생산 미생물 균주 및 바이오공정 개발
• 폐플라스틱 생분해 및 업사이클링 기술 개발
• 바이오플라스틱 생산 기술 개발
• 2종 이상의 미생물 제어 및 유전자 조작 기반 화이트마이크로바이옴 기술 개발

연구성과 - 주요 논문 (* Represents Co-first or corresponding Author)

1. Lee, J. A., Kim, J. Y., Ahn, J. H., Ahn, Y., and Lee, S. Y., “Current advancements in the bio-based production of polyamides”, Trends in Chemistry, 5(12):873-891 (2023).
2. Lee, G. H., Kim, D.-W., Jin, Y. H., Kim, S. M., Lim, E. S., Cha, M. J., Ko, J. K., Gong, G., Lee, S. -M., Um, Y., Han, S. O., and Ahn, J. H., “Biotechnological Plastic Degradation and Valorization Using Systems Metabolic Engineering”. International Journal of Molecular Sciences, 24, 15181 (2023).
3. Jo, Y. Y., Park, S. Y., Gong, G., Roh, S., Yoo, J., Ahn, J. H., Lee, S., Um, Y., Kim, K. H., and Ja, K. K. “Enhanced production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with modulated 3-hydroxyvalerate fraction by overexpressing acetolactate synthase in Cupriavidus necator H16”, International Journal of Biological Macromolecules, 242, 125166 (2023).
4. Choi, Y., Son, H., Hwang, S., Kim, J., Ko, J. K., Gong, G., Ahn, J. H., Um, Y., Han, S. O., and Lee, S. “Hexanoic acid improves the production of lipid and oleic acid in Yarrowia lipolyitca: the benefit of integrating biorefinery with organic waste management”, Environmental Technology & Innovation, 31, 103168 (2023).
5. Ahn, J. H., Jung, K. H., Lim, E. S., Kim, S., M., Han, S. O., Um, Y. “Recent advances in microbial production of medium chain fatty acid from renewable carbon resources: a comprehensive review”, Bioresourse Technology, 381, 129147 (2023).
6. Yi, J., Kim, M., Ahn, J. H., Kim, B., Son, J., Sung, C. “CRISPR/deadCas9-based high-throughput gene doping analysis (HiGDA): A proof of concept for exogenous human erythropoietin gene doping detection”, Talanta, 258, 124455, (2023).
7. Oh, H., Gong, G., Ahn, J. H., Ko, J. K., Lee, S., Um, Y. “Effective hexanol production from carbon monoxide using extractive fermentation with Clostridium carboxidivorans P7”, Bioresoure Technology, 367, 128201, (2023).
8. Lee, J. A.γ, Ahn, J. H.γ, Kim, G. B., and Lee, S. Y. “Metabolic engineering of Mannheimia succiniciproducens for malic acid production using dimethylsulfoxide as an electron acceptor”, Biotechnology and Bioengineering, 123(1), 203-215, (2023).
9. Bang, J. H.γ, Ahn, J. H.γ, Lee, J. A., Hwang, C. H., Kim, G. B., and Lee, S. Y. “Synthetic Formatotrophs for One-Carbon Biorefinery.” Advanced Science, 2100199, 1-15, (2021).
10. Bang, J. H., Hwang, C. H., Ahn, J. H., Lee, J. A., and Lee, S. Y. “Escherichia coli is engineered to grow on CO2 and formic acid.” Nature Microbiology. 5, 1459-1463, (2020).
11. Ahn, J. H.γ, Seo, H.γ, Park, W., Seok, J., Lee, J. A., Kim, W. J., Kim, G. B., Kim, K., and Lee, S. Y. “Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase.” Nature Communications, 11, 1970, (2020).
12. Lee, J. Aγ, Ahn, J. H.γ, Kim, I., Li, S., and Lee, S. Y. "Synthesis, characterization, and application of fully bio-based and biodegradable nylon-4,4 and -5,4", ACS Sustainable Chemistry and Engineering, 8, 5604-5614, (2020).
13. Chae, T. U., Ahn, J. H., Ko, Y. S., Kim, J. W., Lee, J. A., Lee, E. H., and Lee, S. Y. "Metabolic engineering for the production of dicarboxylic acids and diamines", Metabolic Engineering, 58: 2-16 (2020).
14. Lee, J. Aγ, Ahn, J. H. γ, Kim, I., Li, S., and Lee, S. Y. "Separation and purification of three, four, and five carbon diamines from fermentation broth", Chemical Engineering Science, 196: 324-332, (2019).
15. Ahn, J. H., Lee, J. A., Bang, J., and Lee, S. Y., "Membrane engineering via trans-unsaturated fatty acids production improves succinic acid production in Mannheimia succiniciproducens", Journal of Industrial Microbiology and Biotechnology, 45: 555-566, (2018).
16. Ahn, J. H.γ, Bang, J.γ, Kim, W. J., and Lee, S. Y. "Formic acid as a secondary substrate for succinic acid production by metabolically engineered Mannheimia succiniciproducens", Biotechnology and Bioengineering, 114(12):2837-2847, (2017).
17. Kim, W. J.γ, Ahn, J. H.γ, Kim, H. U., Kim, T. Y., and Lee, S. Y. "Metabolic engineering of Mannheimia succiniciproducens for succinic acid production based on elementary mode analysis with clustering", Biotechnology Journal, 12, 1600701, DOI 10.1002/biot.201600701, (2017).
18. Lee, J. W., Yi, J., Kim, T. Y., Choi, S., Ahn, J. H., Song, H., Lee, M. H., and Lee, S. Y. "Homo-succinic acid production by metabolically engineered Mannheimia succiniciproducens", Metabolic Engineering, 38: 409-417, (2016).
19. Choi, S., Song, H., Lim, S. W., Kim, T. Y., Ahn, J. H., Lee, J. W., Lee, M. H., and Lee, S. Y. "Highly selective production of succinic acid by metabolically engineered Mannheimia succiniciproducens and its efficient purification", Biotechnology and Bioengineering, 113(10): 2168-2177, (2016).
20. Ahn, J. H.γ, Jang, Y. S.γ, and Lee, S. Y. "Production of succinic acid by metabolically engineered microorganisms", Current Opinion in Biotechnology, 42: 54-66, (2016).
21. Ahn, J. H.γ, Lim, J. H., Park, J., Oh, E. H., Son, M., Hong, S. and Park, T. H. "Screening of target-specific olfactory receptor and development of olfactory biosensor for the assessment of fungal contamination in grain", Sensors and Actuators B: Chemical, 210, 9-16, (2015).
22. Lim, J. H., Park, J., Ahn, J. H., Jin, H. J., Hong, S. and Park, T. H. "A peptide receptor-based bioelectronic nose for the real-time determination of seafood quality", Biosensors and Bioelectronics, 39, 244-249, (2013).
23. Minty, J. J., Singer, M. E., Scholz, S. A., Bae, C. H., Ahn, J. H., Foster, C. E., James C. L., and Lin, X. N. “Design and characterization of synthetic fungal-bacterial consortia for direct production of isobutanol from cellulosic biomass”, Proceedings of the National Academy of Sciences, 110(36), 14592-14597, (2013).