신진과학자 소개

김 수 만 (Su-Man Kim)

전남대학교 생물교육과 E-mail : kimsm3324@jnu.ac.kr

주요 연구 관심 분야 소개

• 장내 마이크로바이옴–대사/면역질환 관계 및 기전 규명
• 대장에서의 항암, 항염증 기전 연구
• 미생물 및 천연물 유래 신규 면역증진 물질 발굴

연구성과 – 주요논문

• Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis. Su-Man Kim, Shinhye Park, Eun-Young Lee, Jong-Hwan Kim, Ga Seul Lee, Giljae Lee, Seung-Ho Hwang, Dong-Ho Chang, Jae-Geun Lee, Jungwon Hwang, Youngjin Lee, Minsoo Kyung, Eun-Kyoung Kim, Jae-Hoon Kim, Tae-Hwan Kim, Jeong Hee Moon, Byoung-Chan Kim, GwangPyo Ko, Seon-Young Kim, Ji-Hwan Ryu, Jeong-Soo Lee Chul-Ho Lee, Sunghoon Kim, Won-Jae Lee, Myung Hee Kim. Cell Host & Microbe, June 14, 2023, 31 (1021–1037).
• Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling. Lee EY, Kim SM, Hwang JH, Jang SY, Park S, Choi S, Lee GS, Hwang J, Moon JH, Fox PL, Kim S, Lee CH, Kim MH. Nature Communications. 2022 Oct 29;13(1):6455.
• Pulmonary fibrosis model using micro-CT analyzable human PSC-derived alveolar organoids containing alveolar macrophage-like cells. Choi S, Choi J, Cheon S, Song J, Kim SY, Kim JE, Nam DH, Manzar G, Kim SM, Kang HS, Kim KK, Jeong SH, Lee JH, Park EK, Lee M, Lee HA, Kim KS, Park HJ, Oh WK, Park C, Lee CH, Kim EM. Cell Biol Toxicol. 2022 Aug;38(4):557-575.
• TREM2 promotes natural killer cell development in CD3-CD122+NK1.1+ pNK cells. Lee HY, Lee EH, Yi J, Ji KY, Kim SM, Choi HR, Yee SM, Kang HS, Kim EM. BMC Immunol. 2021 May 12;22(1):30.
• Cyclophilin A is an endogenous ligand for the triggering receptor expressed on myeloid cells-2 (TREM2). Ji KY*, Kim SM*, Yee SM*, Kim MJ, Ban YJ, Kim EM, Lee EH, Choi HR, Yun H, Lee CW, Yun CH, Lee CJ, Lee HB, Kang HS. FASEB J. 2021 Apr;35(4):e21479.
• Axl is a key regulator of intestinal γδ T-cell homeostasis. Kim SM, Park M, Yee SM, Ji KY, Lee EH, Nguyen TV, Nguyen TH, Jang J, Kim EM, Choi HR, Yun CH, Kang HS. FASEB J. 2019 Dec;33(12):13386-13397.
• TREM2 Acts as a Tumor Suppressor in Colorectal Carcinoma through Wnt1/β-catenin and Erk Signaling. Kim SM, Kim EM, Ji KY, Lee HY, Yee SM, Woo SM, Yi JW, Yun CH, Choi H, Kang HS. Cancers (Basel). 2019 Sep 6;11(9).
• KGC3P attenuates ovalbumin-induced airway inflammation through downregulation of p-PTEN in asthmatic mice. Lee YS, Yang WK, Yee SM, Kim SM, Park YC, Shin HJ, Han CK, Lee YC, Kang HS, Kim SH. Phytomedicine. 2019 Apr 30; 62:152942.
• Daucosterol suppresses dextran sulfate sodium (DSS)-induced colitis in mice. Int Immunopharmacol. Jang J*, Kim SM*, Yee SM, Kim EM, Lee EH, Choi HR, Lee YS, Yang WK, Kim HY, Kim KH, Kang HS, Kim SH. 2019 Jul 72:124-130.
• Canavalia gladiata and Arctium lappa extracts ameliorate dextran sulphate sodium-induced inflammatory bowel disease by enhancing immune responses. Ji KY, Jang JH, Lee EH, Kim SM, Song HW, Yang WK, Kim HY, Kim KH, Lee YS, Kim DS, Kang HS, Kim SH. Journal of Functional Foods. 2018 Jun 24-33.
• The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways. Lee HJ, Im AR, Kim SM, Kang HS, Lee JD, Chae S. BMC Complement Altern Med. 2018 Jan 30;18(1):39.
• TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Kim SM, Mun BR, Lee SJ, Joh Y, Lee HY, Ji KY, Choi HR, Lee EH, Kim EM, Jang JH, Song HW, Mook-Jung I, Choi WS, Kang HS. Sci Rep. 2017 Sep 11;7(1):11118.
• Blockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer. Lee EH, Ji KY, Kim EM, Kim SM, Song HW, Choi HR, Chung BY, Choi HJ, Bai HW, Kang HS. Sci Rep. 2017 Jul 18;7(1):5759.
• Axl acts as a tumor suppressor by regulating LIGHT expression in T lymphoma. Lee EH, Kim EM, Ji KY, Park AR, Choi HR, Lee HY, Kim SM, Chung BY, Park CH, Choi HJ, Ko YH, Bai HW, Kang HS. Oncotarget. 2017 Mar 28;8(13):20645-20655.
• Axl signaling induces development of natural killer cells in vitro and in vivo. Kim EM, Lee EH, Lee HY, Choi HR, Ji KY, Kim SM, Kim KD, Kang HS. Protoplasma. 2017 Mar;254(2):1091-1101.
• The exceptionally large genome of the harmful red tide dinoflagellate Cochlodinium polykrikoides Margalef (Dinophyceae): determination by flow cytometry. Hong HH, Lee HG, Jo JH, Kim HM, Kim SM, Park JY, Jeon CB, Kang HS, Park MG, Park CG, Kim KY. Algae. 2016, 31(4):373-378
• Bacterial β-(1,3)-glucan prevents DSS-induced IBD by restoring the reduced population of regulatory T cells. Lee KH, Park M, Ji KY, Lee HY, Jang JH, Yoon IJ, Oh SS, Kim SM, Jeong YH, Yun CH, Kim MK, Lee IY, Choi HR, Ko KS, Kang HS. Immunobiology. 2014 Oct;219(10):802-12.
• Formaldehyde exposure impairs the function and differentiation of NK cells. Kim EM, Lee HY, Lee EH, Lee KM, Park M, Ji KY, Jang JH, Jeong YH, Lee KH, Yoon IJ, Kim SM, Jeong MJ, Kim KD, Kang HS. Toxicol Lett. 2013 Nov 25;223(2):154-61.
• Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways. PLoS One. 2012;7(5):e37111.
• Kim SM*, Kim MY*, Ann EJ, Mo JS, Yoon JH, Park HS. Presenilin-2 regulates the degradation of RBP-JK protein through p38 mitogen-activated protein kinase. Mo JS*, Yoon JH*, Hong JA*, Kim MY, Ann EJ, Ahn JS, Kim SM, Baek HJ, Lang F, Choi EJ, Park HS. J Cell Sci. 2012 Mar 1;125(Pt 5):1296-308.
• Regulation of Notch1 signaling by APP intracellular domain facilitates the protein degradation of the Notch1 intracellular domain and RBP-Jk. Kim MY*, Mo JS*, Ann EJ*, Yoon JH, Jung J, Choi YH, Kim SM, Kim HY, Ahn JS, Kim H, Kim K, Hoe HS, Park HS. J Cell Sci. 2011 Jun 1;124(Pt 11):1831-43.
• Serum- and glucocorticoid-inducible Kinase1 (SGK1) controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase. Mo JS, Ann EJ, Yoon JH, Jung J, Choi YH, Kim HY, Ahn JS, Kim SM, Kim MY, Hong JA, Seo MS, Lang F, Choi EJ, Park HS. J Cell Sci. 2011 Jan 1;124(Pt 1):100-12.