연구성과 - 주요 논문 (* Represents Co-first or corresponding Author)
Aleksi Husso, Tiina Pessa‑Morikawa, Ville Mikael Koistinen, Olli Kärkkäinen, Hyuk Nam Kwon, Leo Lahti, Antti Iivanainen, Kati Hanhineva, Mikael Niku, “Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta”, BMC biology, 21(1), 207. (2023)
Jinsuk Bae, Hyuk Huh, Minji Noh, Seongmin Kang, Eun Hee Park, Je Hun Song, Kyung Sun Park, Jong Ha Park, Jong Soo Lee, Hyuknam Kwon, Hoseok Koo, and Kyung Don Yoo, “Association between food insecurity and risk of chronic diseases affecting the kidney in older Korean patients”, Clinical Nephrology, 100: 165-176, (2023)
Hyo Jin Kim, Munki Choo, Hyuk Nam Kwon, Kyung Don Yoo, Yunmi Kim, Bodokhsuren Tsogbadrakh, Eunjeong Kang, Sunghyouk Park, Kook-Hwan Oh, “Metabolomic profiling of overnight peritoneal dialysis effluents predicts the peritoneal equilibration test type”, Scientific Reports, 13(1), 3803, (2023)
Hyuk Nam Kwon*, Kristen Kurtzeborn*, Vladislav Iaroshenko, Xing Jin, Abigail Loh, Nathalie Escande-Beillard, Bruno REVERSADE, Sunghyouk Park, Satu Kuure, “Omics profiling identifies MAPK/ERK pathway as a gatekeeper of nephron progenitor metabolism”, Development, 149(19), (2022)
Kristen Kurtzeborn*, Hyuk NamKwon*, Vladislav Iaroshenko, Imrul Faisal, Martin Ambrož, Xing Jin, Talha Qureshi, Jussi Kupari, Anneliis Ihermann-Hella, Juho Väänänen, Henna Tyynismaa, Iva Boušová, Sunghyouk Park, Satu Kuure, “Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK-targets in embryonic kidney”, BMC biology, 20(1), 112. (2022)
Sehyun Oh, Youngup Cho, Minsun Chang*, Sunghyouk Park*, Hyuknam Kwon*, “Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation”, Metabolites, 11(8), 480. (2021)
Hyuk Nam Kwon*, Hyuk Lee*, Ji Won Park, Young-Ho Kim, Sunghyouk Park, Jae J. Kim, “Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach”, Cancers, 12(10), 2904. (2020)
Sunmi Kang*, Hyuk Nam Kwon, Soeun Kang, Sunghyouk Park, “Interaction between IDH1 WT and calmodulin and its implications for glioblastoma cell growth and migration”, Biochemical and Biophysical Research Communications 524(1):224-230. (2020)
Dae Wui Yoon*, Hyuk Nam Kwon*, Xing Jin, Jin Kwan Kim, Seung Ku Lee, Sunghyouk Park, Chang-Ho Yun, Chol Shin, “Untargeted metabolomics analysis of rat hippocampus subjected to sleep fragmentation” Brain Research Bulletin 153, 74-83. (2019)
Eun Ran Kim*, Hyuk Nam Kwon*, Hoonsik Nam, Jae J. Kim, Sunghyouk Park, Young-Ho Kim, “Urine-NMR metabolomics for screening of advanced colorectal adenoma and early stage colorectal cancer.” Scientific Reports 9(1). (2019)
Kristen Kurtzeborn*, Hyuk Nam Kwon*, Satu Kuure, “MAPK/ERK Signaling in Regulation of Renal Differentiation.” International Journal of Molecular Sciences 20(7):1779. (2019)
Anneliis Ihermann-Hella, Tsuyoshi Hirashima, Jussi Kupari, Kristen Kurtzeborn, Hao Li, Hyuk Nam Kwon, Cristina Cebrian, Abdul Soofi, Arvydas Dapkunas, Ilkka Miinalainen, Gregory R. Dressler, Michiyuki Matsuda, Satu Kuure, “Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation” Stem Cell Reports 11(4). (2018)
Inseon Ryoo*, Hyuknam Kwon*, Soo Chin Kim, Seung Chai Jung, Jeong A Yeom, Hwa Seon Shin, Hye Rim Cho, Tae Jin Yun, Seung Hong Choi, Chul-Ho Sohn, Sunghyouk Park, Ji-hoon Kim, “Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer” Scientific Reports 6:30075. (2016)
Hyuk Nam Kwon*, Hong-Duc Phan*, Wen Jun Xu, Yoon-Joo Ko, Sunghyouk Park, “Application of a Smartphone Metabolomics Platform to the Authentication of Schisandra sinensis: Schisandra sinensis Authentication by Smartphone Metabolomics Platform” Phytochemical Analysis 27(3-4): 199-205. (2016)
Hyuknam Kwon*, Sehyun Oh*, Xing Jin, Yong Jin An, Sunghyouk Park, "Cancer metabolomics in basic science perspective" Archives of Pharmacal Research, 38(3): 372-380. (2015)
Hyuk Nam Kwon*, Yeon Ji Lee*, Ju-Hee Kang*, Ji-ho Choi, Yong Jin An, Sunmi Kang, Dae Hyun Lee, Young Ju Suh, Yoonseok Heo, Sunghyouk Park, "Prediction of Glycated Hemoglobin Levels at 3 Months after metabolic Surgery Based on the 7-Day Plasma Metabolic Profile" PloS One, 9(11):e109609. (2014)
Hyuknam Kwon, Jooeun Park, Yongjin An, Jaeho Sim, Sunghyouk Park, "A smartphone metabolomics platform and its application to the assessment of cisplatin-induced kidney toxicity" Analytica Chimica Acta 845: 15-22. (2014)
He Wen*, Hyuk Nam Kwon*, Sunghyouk Park, "A new mechanism in the binding between Homer3 EVH1 domain and inositol 1, 4, 5 trisphosphate receptor suppressor domain" Biochemistry and Cell Biology 92(3): 163-171. (2014)
Xing Jin*, Sunmi Kang*, Hyuknam Kwon*, Sunghyouk Park, "Heteronuclear NMR As a 4-in-1 analytical platform for detecting modification-specific signatures of therapeutic insulin formulations" Analytical Chemistry 86(4): 2050-2056. (2014)
Byung-Hak Yoon, Yun-Hui Jeon, Byunghee Hwang, Hyuknam Kwon, Senyon Choe, Zungyoon Yang, "Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD)" BMB reports 46(9): 465. (2013)
Soohyun Um, Young-Joo Kim, Hyuknam Kwon, He Wen, Seong-Hwan Kim, Hak Cheol Kwon, Sunghyouk Park, Jongheon Shin, Dong-Chan Oh, "Sungsanpin, a lasso peptide from a deep-sea streptomycete" Journal of Natural Products 76(5): 873-879. (2013)
Sung-Lim Yu, Yong Jin An, Hey-ji Yang, Mi-Sun Kang, Ho-Yeol Kim, He Wen, Xing Jin, Hyuk Nam Kwon, Kyung-Jin Min, Sung-Keun Lee, "Alanine-metabolizing enzyme Alt1 is critical in determining yeast life span, as revealed by combined metabolomic and genetic studies" Journal of Proteome Research 12(4): 1619-1627. (2013)
Hye-ji Yang, Myung-Joo Choi, He Wen, Hyuk Nam Kwon, Kyung Hee Jung, Sang-Won Hong, Joon Mee Kim, Soon-Sun Hong, Sunghyouk Park, "An effective assessment of simvastatin-induced toxicity with NMR-based metabonomics approach" PloS One 6: e16641. (2011)
He Wen, Hye-Ji Yang, Myung-Joo Choi, Hyuk Nam Kwon, Min Ah Kim, Soon-Sun Hong, Sunghyouk Park, “Identification of Urinary Biomarkers Related to Cisplatin-Induced Acute Renal Toxicity Using NMR-Based Metabolomics” Biomolecules & Therapeutics 19(1): 38-44. (2011)
Sunmi Kang, Hyuknam Kwon, He Wen, Youngmin Song, Dominique Frueh, Hee-Chul Ahn, Seung Hyun Yoo, Gerhard Wagner, Sunghyouk Park, "Global dynamic conformational changes in the suppressor domain of IP3 receptor by stepwise binding of the two lobes of calmodulin" The FASEB Journal 25(3): 840-850. (2011)
Hyuk Nam Kwon, Mina Kim, He Wen, Sunmi Kang, Hye-ji Yang, Myung-Joo Choi, Hee Seung Lee, DalWoong Choi, In Suh Park, Young Ju Suh, Soon-Sun Hong , Sunghyouk Park, "Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach" Kidney International 79(5): 529-537. (2011)
He Wen, Sung Soo Yoo, Jinho Kang, Hee Goo Kim, Jin-Seok Park, Seok Jeong, Jung Il Lee, Hyuk Nam Kwon, Sunmi Kang, Don-Haeng Lee, Sunghyouk Park, "A new NMR-based metabolomics approach for the diagnosis of biliary tract cancer" Journal of Hepatology 52(2): 228-233. (2010)
Jinho Kang, Moon-Young Choi, Sunmi Kang, Hyuk Nam Kwon, He Wen, Chang Hoon Lee, Minseok Park, Susanne Wiklund, Hyo Jin Kim, Sung Won Kwon, Sunghyouk Park, "Application of a 1H nuclear magnetic resonance (NMR) metabolomics approach combined with orthogonal projections to latent structure-discriminant analysis as an efficient tool for discriminating between Korean and Chinese herbal medicines" Journal of Agricultural and Food Chemistry 56(24): 11589-11595. (2008)
Sunmi Kang, Jinho Kang, Hyuknam Kwon, Dominique Frueh, Seung Hyun Yoo, Gerhard Wagner, Sunghyouk Park, "Effects of Redox Potential and Ca2+ on the Inositol 1, 4, 5-Trisphosphate Receptor L3-1 Loop Region IMPLICATIONS FOR RECEPTOR REGULATION" Journal of Biological Chemistry 283(37): 25567-25575. (2008)
Jinho Kang, Sunmi Kang, Hyuk Nam Kwon, Wen He, Sunghyouk Park, "Distinct interactions between ubiquitin and the SH3 domains involved in immune signaling" Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1784(9): 1335-1341. (2008)
Jinho Kang, Seoyoung Lee, Sunmi Kang, Hyuk Nam Kwon, Jeong Hill Park, Sung Won Kwon, Sunghyouk Park, "NMR-based metabolomics approach for the differentiation of ginseng (Panax ginseng) roots from different origins" Archives of Pharmacal Research31(3): 330-336. (2008)
연구성과 – 주요특허
Sunghyouk Park; Hyuk Nam Kwon; Jooeun Park, 2015, “the metabolomics portable analysis apparatus and the metabolomics analysis system using the same, the metabolomics analysis method using the same”, Korea, Patent No. 1015607210000, Oct 08, 2015
Sung Won Kwon; Sunghyouk Park; Jinho Kang; Sunmi Kang; Hyuk Nam Kwon; Sin Jeong Kang; In Ho Kang; Young Hoon Sim; Se Wook Oh; Byung Hee Lee, 2009, “ORIGIN DISCRIMINATION METHOD OF HERBAL MEDICINE”, Korea, Patent No. 10-0905414, Sep 02, 2009