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2023 September Vol.36 No.3 ISSN 1598-8384


신진과학자 소개

홍 성 욱 (Sung-Wook Hong)

연세대학교 생명공학과 E-mail :

  • 2008.03 ~ 2012.08.

    포항공과대학교, 생명과학과, 박사 (석·박사통합과정)

  • 2001.03 ~ 2008.02.

    포항공과대학교, 생명과학과, 학사

  • 2023.03 ~ 현재.

    연세대학교, 생명시스템대학, 생명공학과, 조교수

  • 2018.08 ~ 2023.02.

    University of Minnesota, Postdoc associate

  • 2013.05 ~ 2018.04.

    기초과학연구원(IBS), 면역미생물공생연구단, 연구위원

주요 연구 관심 분야 소개

  • 음식 항원에 대한 면역 관용 및 염증 반응 유발 기전에 대한 연구
  • 공생 세균에 대한 면역 관용 기전에 대한 연구

연구성과 - 주요 논문

  1. Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction. Hong SW, Krueger PD, Osum KC, Dileepan T, Herman A, Mueller DL, Jenkins MK. Nature. 2022 607,762-768.
  2. Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production. Lee M, Ko HJ, Hong SW, Park J, Ham S, Kim M, Kwon DI, Lee MS, Roh TY, Soon Kim K, Lee YJ. Sci Rep. 2022 May 6;12(1):7443.
  3. Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection. Geng Q, Tai W, Baxter VK, Shi J, Wan Y, Zhang X, Montgomery SA, Taft-Benz SA, Anderson EJ, Knight AC, Dinnon KH 3rd, Leist SR, Baric RS, Shang J, Hong SW, Drelich A, Tseng CK, Jenkins M, Heise M, Du L, Li F. PLoS Pathog. 2021 Jul 26;17(7):e1009733.
  4. Listeria monocytogenes establishes commensalism in germ-free mice through the reversible downregulation of virulence gene expression. Cho K, Spasova D, Hong SW, O E, Surh CD, Im SH, Kim KS. Front Immunol. 2021 May 3;12:666088.
  5. Two sequential activation modules control the differentiation of protective T helper-1(Th1) cells. Krueger PD, Goldberg MF, Hong SW, Osum KC, Langlois RA, Kotov DI, Dileepan T, Jenkins MK. Immunity. 2021 Apr 13;54(4):687-701.e4.
  6. Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses. Joag V, Wijeyesinghe S, Stolley JM, Quarnstrom CF, Dileepan T, Soerens AG, Sangala JA, O'Flanagan SD, Gavil NV, Hong SW, Bhela S, Gangadhara S, Weyu E, Matchett WE, Thiede J, Krishna V, Cheeran MC, Bold TD, Amara R, Southern P, Hart GT, Schifanella L, Vezys V, Jenkins MK, Langlois RA, Masopust D. J Immunol. 2021 Mar 1;206(5):931-935.
  7. Hybrid Fc-fused interleukin-7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy. Kim JH, Kim YM, Choi D, Jo SB, Park HW, Hong SW, Park S, Kim S, Moon S, You G, Kang YW, Park Y, Lee BH, Lee SW. Clin Transl Immunology. 2020 Sep 4;9(9):e1168.
  8. Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells. Ko HJ*, Hong SW*, , Verma R, Jung J, Lee M, Kim N, Kim D, Surh CD, Kim KS, Rudra D, Im SH. Front Immunol. 2020 Aug 11;11:1897. *equal contribution
  9. TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity. Lee JY, Lee E, Hong SW, Kim D, Eunju O, Sprent J, Im SH, Lee YJ, Surh CD. Oncoimmunology. 2019 Nov 4;9(1):1681869.
  10. Bcl11b prevents catastrophic autoimmunity by controlling multiple aspects of a regulatory T cell gene expression program. Hasan SN, Sharma A, Ghosh S, Hong SW, Roy-Chowdhuri S, Im SH, Kang K, Rudra D. Sci Adv. 2019 Aug 7;5(8):eaaw0706.
  11. Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota. Hong SW*, O E, Lee JY, Lee M, Han D, Ko HJ, Sprent J, Surh CD, Kim KS*. Sci Adv. 2019 May 22;5(5):eaaw1507. *co-correspondence
  12. Interleukin-2/antibody complex expanding Foxp3+ regulatory T cells exacerbates Th2-mediated allergic airway inflammation. Hong SW*, O E*, Lee JY, Yi J, Cho K, Kim J, Kim D, Surh CD, Kim KS. BMB Rep. 2019 Apr;52(4):283-288. *equal contribution
  13. .Unregulated antigen-presenting cell activation by T cells breaks self tolerance. Yi J, Jung J, Hong SW, Lee JY, Han D, Kim KS, Sprent J, Surh CD. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):1007-1016.
  14. Cost-effective production of tag-less recombinant protein in Nicotiana benthamiana. Islam MR, Kwak JW, Lee JS, Hong SW, Khan MRI, Lee Y, Lee Y, Lee SW, Hwang I. Plant Biotechnol J. 2019 Jun;17(6):1094-1105.
  15. Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells. Kim J, Lee JY, Cho K, Hong SW, Kim KS, Sprent J, Im SH, Surh CD, Cho JH. Front Immunol. 2018 Aug 23;9:1907.
  16. Drug Repositioning to Alleviate Systemic Inflammatory Response Syndrome Caused by Gram-Negative Bacterial Outer Membrane Vesicles. Kim JH, Lee J, Park KS, Hong SW, Gho YS. Adv Healthc Mater. 2018 Jul;7(13):e1701476.