University of Illinois at Urbana-Champaign, Food Science & Human Nutrition, 박사
[경 력]
2009 ~ 2012.
롯데케미칼, 연구원
2018 ~ 2022.
Washington University School of Medicine, 박사후연구원
2022 ~ 현재.
국민대학교 바이오발효융합학과, 조교수
주요 연구 관심 분야 소개
인체 또는 식품 마이크로바이옴 구조 및 기능 개선
신규 뉴트라슈티컬 합성경로 발굴 및 생합성 최적화
맞춤형 합성 프로바이오틱 플랫폼 구축
연구성과 – 주요논문
Kwak S, Crook N, Yoneda A, Ahn N, Ning J, Cheng J, Dantas G. Mining novel terpene synthases from metagenomes. Biotechnol Biofuels. 2022;15:104.
Kwak S, Robinson SJ, Lee JW, Lim H, Wallace CL, Jin YS. Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering. Biomaterials. 2022;282:121379.
Kwak S, Mahmud B, Dantas G. A tunable and expandable transactivation system in probiotic yeast Saccharomyces boulardii. ACS Synth Biol. 2021;11: 508-514.
Kwak S, Choi J, Hink T, Reske KA, Blount K, Jones C, Bost MH, Sun X, Burnham CD, Dubberke ER, Dantas G. Impact of investigational microbiota therapeutic RBX2660 on the gut microbiome and resistome revealed by a placebo-controlled clinical trial. Microbiome. 2020;8:125.
Lee JW, Kwak S, Liu JJ, Yu S, Yun EJ, Kim DH, Liu C, Kim KH, Jin YS. Enhanced 2'-fucosyllactose production by engineered Saccharomyces cerevisiae using xylose as a co-substrate.Metab Eng. 2020;62:322-329.
Kwak S, Yun EJ, Lane S, Oh EJ, Kim KH, Jin YS. Redirection of glycolytic flux enhances isoprenoid production in Saccharomyces cerevisiae. Biotechnol J. 2019;15:e1900173.
Liu JJ, Zhang GC, Kwak S, Oh EJ, Yun EJ, Chomvong K, Cate JHD, Jin YS. Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation. Nat Commun. 2019;10:1356
Kwak S, Jo JH, Yun EJ, Jin YS, Seo JH. Production of biofuels and chemicals from xylose using native and engineered yeast strains. Biotechnol Adv. 2019; 37:271-283.
Liu JJ, Kwak S, Pathanibul P, Lee JW, Lim H, Yu S, Yun EJ, Kim KH, Jin YS. Biosynthesis of a functional human milk oligosaccharide, 2’-fucosyllactose and its precursor L-fucose, using Saccharomyces cerevisiae. ACS Synth Biol. 2018;7:2529-2536.
Kwak S, Kim SR, Xu H, Zhang GC, Kim H, Lane S, Jin YS. Enhanced isoprenoid production from xylose by engineered Saccharomyces cerevisiae. Biotechnol Bioeng. 2017;114:2581-2591.
Kwak S, Jin YS. Production of fuels and chemicals from xylose by engineered Saccharomyces cerevisiae: a review and perspective. Microb Cell Fact. 2017;16:82.
Kwak S, Park YC, Seo JH. Biosynthesis of 3-hydroxypropionic acid from glycerol in recombinant Escherichia coli expressing Lactobacillus brevis dhaB and dhaR gene clusters and E. coli K-12 aldH. Bioresour Technol. 2013;135:432-439.
연구성과 – 주요특허
Dantas G, Kwak S, Virgin H. Engineered microorganisms and methods of making and using same. WO 2020/061389. 2020
Jin YS, Liu JJ, Yu S, Yun EJ, Kwak S, Kim KH, Lee J. Engineered microorganisms for production of 2' fucosyllactose and l-fucose. WO 2019/222391. 2019
