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2022 June Vol.35 No.2 ISSN 1598-8384

신진과학자

신진과학자 소개

김 래 현 (Raehyun Kim)

홍익대학교 세종캠퍼스 바이오화학공학과 E-mail : raehyunkim@hongik.ac.kr

[학 력]

2000 ~ 2004
서울대학교 응용화학부, 학사
2004 ~ 2006
서울대학교 화학생물공학부, 석사
2009 ~ 2016
University of Illinois at Urbana-Champaign, Chemical and Biomolecular Engineering, 박사

[경 력]

2006 ~ 2007
(SK) 하이닉스, 연구원
2007 ~ 2009
한국과학기술연구원, 연구원
2016 ~ 2019
University of North Carolina at Chapel Hill, 박사후 연구원
2020 ~ 2021
University of Washington, Seattle, 박사후 연구원

주요 연구 관심 분야 소개

장내미생물
박테리아-동물세포 공배양
미세생리학 시스템
소화기 및 상피세포 조직 모델 개발

연구성과 – 논문

S. Mestril, R. Kim, S. S. Hinman, S. M. Gomez, N. L. Allbritton, “Stem/proliferative and differentiated cells within primary murine colonic epithelium display distinct intracellular free Ca 2+ signal codes”, Advanced Healthcare Material, 2101318 (2021)
J. S. Dutton, S. S. Hinman, R. Kim, P. J. Attayek, M. Maurer, C. E. Sims, N. L. Allbritton, “Hyperglycemia minimally alters primary self-renewing human colonic epithelial cells while TNFα-promotes severe intestinal epithelial dysfunction”, Integrative Biology, 13, 139-152 (2021)
S. S. Hinman, Y. Wang, R. Kim, N. L. Allbritton, “In vitro generation of self-renewing human intestinal epithelia over planar and shaped collagen hydrogels", Nature Protocols, 16, 352-382 (2021)
S. S. Hinman, R. Kim, Y. Wang, K. S. Phillips, P. J. Attayek, N. L. Allbritton, “Microphysiological system design: simplicity is elegance”, Current Opinion in Biomedical Engineering, 13, 94-102 (2020)
R. Kim, P. J. Atteyak, Y. Wang, K. L. Furtado, R. Tamayo, C. E. Sims, N. L. Allbritton, “An in vitro intestinal platform with a self-sustaining oxygen gradient to study the human gut/microbiome interface”, Biofabrication, 12, 015006 (2020)
Y. Wang, R. Kim, C. E. Sims, N. L. Allbritton, “Building a thick mucus hydrogel layer to improve the physiological relevance of in vitro primary colonic epithelial models”, Cellular and Molecular Gastroenterology and Hepatology, 8, 653-655.e5 (2019)
J. S. Dutton, S. S. Hinman, R. Kim, Y. Wang, N. L. Allbritton, “Primary cell-derived intestinal models: recapitulating physiology”, Trends in Biotechnology, 37, 744-760 (2019)
Y. Wang, R. Kim, S. J. Hwang, J. Dutton, C. E. Sims, N. L. Allbritton, “Analysis of interleukin 8 secretion by a stem-cell-derived human-intestinal-epithelial-monolayer platform”, Analytical Chemistry, 90, 11523-11530 (2018)
R. Kim, Y. Wang, S. J. Hwang, P. J. Attayek, N. M. Smiddy, M. I. Reed, C. E. Sims, N. L. Allbritton, “Formation of arrays of planar intestinal crypts possessing a stem cell compartment and differentiated cell zone”, Lab on a Chip, 18, 2202-2213 (2018)
Y. Wang, R. Kim, S. S. Hinman, B. Zwarycz, S. T. Magness, N. L. Allbritton, “Bioengineered systems and designer matrices that recapitulate the intestinal stem cell niche”, Cellular and Molecular Gastroenterology and Hepatology, 5, 440-453.e1 (2018)
Y. Wang, R. Kim, D. B. Gunasekara, M. I. Reed, M. DiSalvo, D. L. Nguyen, S. J. Bultman, C. E. Sims, S. T. Magness, N. L. Allbritton, “Formation of human colonic crypt array by application of chemical gradients across a shaped epithelial monolayer”, Cellular and Molecular Gastroenterology and Hepatology, 5, 113-130 (2018)
V. Mirshafiee, R. Kim, M. Mahmoudi, M. L. Kraft, “The importance of selecting a proper biological milieu for protein corona analysis in vitro: human plasma vs. human serum”, International Journal of Biochemistry and Cell biology, 75, 188-195 (2016)
V. Mirshafiee*, R. Kim*, S. Park, M. Mahmoudi, M. L. Kraft, “Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake”, Biomaterials, 75, 295-304 (2016) *equally contributed
J. F. Frisz, K. Lou, H. A. Klitzing, W. P. Hanafin, V. Lizunov, R. L. Wilson, K. J. Carpenter, R. Kim, I. D. Hutcheon, J. Zimmerberg, P. K. Weber, M. L. Kraft, “Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts”, Proceedings of the National Academy of Sciences of the United States of America, 110, E613-E622 (2013)
R. Kim*, K. Lou*, M. L. Kraft, “A new long wavelength borondipyrromethene (BODIPY) sphingosine for studying sphingolipid dynamics in live cells”, The Journal of Lipid Research, 54, 265-275 (2013) *equally contributed
R. Kim, C. Kim, S. Lee, J. Kim, and I. W. Kim, “In-situ atomic force microscopy study on the crystallization of calcium carbonate modulated by poly(vinyl alcohol)s”, Crystal Growth and Design, 9, 4584-4587 (2009)
J. Seo, H. Lee, J. Jeon, Y. Jang, R. Kim, K. Char, J. Nam, “Tunable layer-by-layer polyelectrolyte platform for comparative cell assays”, Biomacromolecules, 10, 2254-2260 (2009)
J. Cho, H. Jang, B. Yeom, H. Kim, R. Kim, S. Kim, K. Char, F. Caruso, “Modulating the pattern quality of micropatterned multilayer films prepared by layer-by-layer self-assembly”, Langmuir, 22, 1356-1364 (2006)

연구성과 - 특허

PCT/US2019/033955 (U.S. Provisional Patent Application Serial No. 62/676418), “Formation of arrays of planar intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone”, N. L. Allbritton, Y. Wang, R. Kim, application filed
PCT/US2019/032393 (U.S. Provisional Patent Application Serial No. 62/671661), “Device, systems and apparatuses for generating self-sustaining hypoxic conditions and gaseous and nongaseous chemical gradients for in vitro cell culture”, N. L. Allbritton, Y. Wang, R. Kim, P. J. Atteyak, application filed