책임교수 소개

[학력]

• 2007

  전남대학교 의과대학 미생물학교실 의학박사

본 연구자는 박사학위 이후 학문후속양성세대, 리서치펠로우 연구과제를 수혜 받아 EPEC/EHEC 핵심독력인자 발현 전사기전 규명 하였음. 20년간 인체 감염 세균의 병원성 인자 전사기전 메커니즘 연구를 수행하였고 지금까지 국제전문학술지를 총 약 56편 발표하였으며, 최근 3년간 Acinetobacter baumannii 병인론 및 항생제 내성 기전 관련하여 15편 발표했으며, 다수의 특허 출원 및 등록(PCT포함)함.

교수 임용이후 교육부 기본연구 과제를 수혜받아 다제내성 아시네토박터 바우마니의 독성인자인 OmpA의 발현조절 기전과 stringent response에 신호전달인 ppGpp에 의한 아시네토박터 마우마니의 생물막 형성, 표면 운동성, 동물세포 부착, 독성 등 병원성 인자에 상위 조절자임을 확인하였으며, 이는 항생제 다제내성 아시네토박터 바우마니의 새로운 항바이러스의 표적임을 제시하여 (Microorganisms, BBRC, J Antimicrob Chemother 2020 교신저자, Virulence , Front Cell Infect Microbiol, Viruses 2021 교신저자) 게제함.

* 생물학연구정보센터(BRIC) 한빛사에 4편의 논문이 소개됨

실험실 구성원

• 연구책임자 : 신민상
• 박사후 연구원: Midul Md. Islam
• 대학원생: 김경민(박사수료), 김두영(석사2), 방승혁(석사1), 김정아(석사1), Samia Akter(석/박사통합1)

연구분야 소개

대표 연구성과 - 논문

- First-author/Corresponding-author

• ppGpp signaling plays a critical role in virulence of Acinetobacter baumannii. Virulence. 2021 Dec;12(1):2122-2132
• Characterization of a Novel Phage ΦAb1656-2 and Its Endolysin with Higher Antimicrobial Activity against Multidrug-Resistant Acinetobacter baumannii. Viruses. 2021 Sep 16;13(9):1848.
• LeuO, a LysR-Type Transcriptional Regulator, Is Involved in Biofilm Formation and Virulence of Acinetobacter baumannii. Front. Cell. Infect. Microbiol. 2021 October 11:738706
• Transcriptional regulation of Salmochelin glucosyltransferase by Fur in Salmonella. BBRC. 2020 Aug 13;529(1):70-76.
• Transcriptional Regulation of the Outer Membrane Protein A in Acinetobacter baumannii. Microorganisms. 2020 May 11;8(5). pii: E706.
• Role of ppGpp-regulated efflux genes in Acinetobacter baumannii. J Antimicrob Chemother. 2020 May 1;75(5):1130-1134.
• Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain. Int J Mol Sci. 2020 Mar 16;21(6).
• Crystal structure of an ASCH protein from Zymomonas mobilis and its ribonuclease activity specific for single-stranded RNA. Sci Rep. 2017 Sep 26;7(1):12303.
• The mechanism underlying Ler-mediated alleviation of gene repression by H-NS. BBRC. 2017 Jan 29;483(1):392-396.
• Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation. Endocrinol Metab. 2017 Mar;32(1):11-17.
• Amino acid residues in the Ler protein critical for derepression of the LEE5 promoter in enteropathogenic E. coli. J Microbiol. 2016 Aug;54(8):559-64.
• Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16359-64.
• Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization. J Infect Dis. 2014 Sep 1;210(5):793-802.
• DNA looping-dependent autorepression of LEE1 P1 promoters by Ler in enteropathogenic Escherichia coli (EPEC) Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2586-95
• Crystal structure and CRISPR RNA-binding site of the Cmr1 subunit in the Cmr interference complex. (2014) Acta Crystallogr.,Sect.D 70: 535-543
• Crystal structure of Cas1 from Archaeoglobus fulgidus and its functional implications. BBRC. 2013 Nov 29;441(4):720-5.
• Gene silencing by H-NS from distal DNA site. Mol Microbiol. 2012 Nov;86(3):707-19.
• Crystal structure of a Cas6 paralogous protein from Pyrococcus furiosus. Proteins. 2012 Jul;80(7):1895-900.
• DNA looping-mediated repression by histone-like protein H-NS: specific requirement of Esigma70 as a cofactor for looping. Genes Dev. 2005 Oct 1;19(19):2388-98.
• Repression of deoP2 in Escherichia coli by CytR: conversion of a transcription activator into a repressor. EMBO J. 2001 Oct 1;20(19):5392-9.