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2022 March Vol.35 No.1 ISSN 1598-8384

신진과학자

신진과학자 소개

한 경 호 (Kyung Ho Han)

한남대학교 생명시스템과학과 E-mail : kyungho1@hnu.kr

[학력]

1992 ~ 1999
강원대학교 축산학과, 학사
2000 ~ 2002
서울대학교 농생명공학부, 석사
2005 ~ 2011
서울대학교 생물화학공학, 박사

[경력]

2001 ~ 2004
대웅제약 생명과학연구소, 선임연구원
2004 ~ 2006
International Vaccine Institute, 연구원
2006 ~ 2012
식품의약품안전처, 보건연구사
2012 ~ 2019
The Scripps Research Institute, Staff Scientist
2019 ~ 2020
울산대학교 의과대학, 연구조교수
2020 ~ 2020
한국과학기술원, 연구조교수
2020 ~ 현재
한남대학교 생명시스템과학과, 조교수

주요 연구 관심 분야 소개

암 항체치료제 연구 및 개발
줄기세포 분화 유도 및 재생의료 항체치료제 연구 및 개발
항체의약품 기준 및 시험방법 기술개발
항체 기반 체외진단 기술 개발

연구성과 - 주요 논문

1. Kyung Ho Han, Evaluation of human papillomavirus (HPV) genotyping assays using type‑specifc HPV L1 reference DNA, Genes & Genomics, 2021, 43, 775-781.
2. You-Rim Cha, Saba Sajjad, Kyung Ho Han, Tae-Sung Yoon, Heung-Seon Shin, Sunghyun Kang, Spreader-CDR system for efficient, reproducible, and frugal western blot, Electrophoresis, DOI 2021, 10.1002/elps.202000380.
3. Haruka Miki, Kyung Ho Han, David Scott, Michael Croft, Young Jun Kang, 4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis, 2020, Journal of Immunology, 204(7), 1892-1903.
4. Kyung Ho Han, Britni M. Arlian, Chih-Wei Lin, Hyun Yong Jin, Geun-Hyung Kang, Sahmin Lee, Peter C. W. Lee, Richard A. Lerner, Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-like Cells in Heart, 2020, Cells, 9(1), 256.
5. Chih-Wei Lin , Jia Xie , Ding Zhang , Kyung Ho Han , Geramie Grande , Nicholas C. Wu , Zhuo Yang , Kyungmoo Yea , Richard A. Lerner, Immunity against cancer cells may promote their proliferation and metastasis, 2020, PNAS, 117(1), 426-431.
6. Bo-Ram Bang*, Kyung Ho Han*, Goo-Young Seo, Mitchell Kronenberg, Michael Croft, Young Jun Kang (*equal contribution), The protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation, 2019, Scientific Reports, 9, Article number: 17838.
7. Kyung Ho Han, Britni M. Arlian, Matthew S. Macauley, James C. Paulson, Richard A. Lerner,
Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid β. 2018, PNAS, 115(3),E372-E381.
8. Kyung Ho Han, Rosana Gonzalez-Quintial, Yingjie Peng, Roberto Baccala, Argyrios N. Theofilopoulos, and Richard A. Lerner, An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages. 2016, FASEB J, Feb;30(2):738-47.
9. Young Jun Kang, Bo-Ram Bang, Kyung Ho Han, Lixin Hong, Eun-Jin Shim, Jianhui Ma, Richard A. Lerner, and Motoyuki Otsuka, Regulation of NKT cell-mediated immune responses to tumors and liver inflammation by mitochondrial PGAM5−Drp1 signaling. 2015, Nature Communications, 6:8371
10. Yingjie Peng, Wenwen Zeng, Hui Ye, Kyung Ho Han, Venkatasubramanian Dharmarajan, Scott Novick, Ian A. Wilson, Patrick R. Griffin, Jeffrey M. Friedman, Richard A. Lerner, A General Method for Insertion of Functional Proteins Within Proteins Via Combinatorial Selection of Permissive Junctions. 2015, Cell Chemical Biology, 22, 1-10
11. Richard A. Lerner, Rajesh K. Grover, Hongkai Zhang, Jia Xie, Kyung Ho Han, Yingjie Peng and Kyungmoo Yea, Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates. 2015, Quarterly Reviews of Biophysics, 48, 389-394.

연구성과 - 특허

1. 갈색지방세포 분화 유도 항체 및 이를 유효성분으로 포함하는 대사성 질환 예방 또는 치료용 조성물 (등록번호 10-2201368)
2. Methods and compositions related to In Vivo selection of functional molecules (PCT/US2017/047585)
3. Antibodies for Generating Anti-Inflammatory Macrophage and Related Uses (PCT/US16/51290)