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2022 March Vol.35 No.1 ISSN 1598-8384


신진과학자 소개

이 준 구 (Joongoo Lee)

포항공과대학교 화학공학과 E-mail :

[학 력]
  • 2000 ~ 2006

    연세대학교 화학과, 학사

  • 2006 ~ 2008

    한국과학기술원 화학과, 석사

  • 2011 ~ 2015

    University of Oxford, Chemical Biology, 박사

[경 력]
  • 2010 ~ 2011

    연세대학교 화학과, 연구원

  • 2015 ~ 2016

    Universtiy of Oxford, 박사후연구원

  • 2016 ~ 2021

    Northwestern University, 박사후연구원

  • 2021.2 ~ 현재

    포항공과대학교 화학공학과, 조교수

주요 연구 관심 분야 소개

  • 무세포생물학, 생화학, 유기화학
  • 비천연아미노산 합성
  • 효소 및 리보솜 재설계

연구성과 - 대표성과

  • 1. C. Kofman†, J. Lee†, M. C. Jewett, Engineering molecular translation systems, Cell Systems 2021, 12, 593-607 (†: equally contributed).
  • 2. J. Lee†, K. J. Schwarz†, H. Yu, A. Krüger, E. V. Anslyn, A. D. Ellington, J. S. Moore, M. C. Jewett, Ribosome-mediated incorporation of fluorescent amino acids into peptides in vitro, Chem. Commun. 2021, 57, 2661-2664 (†: equally contributed).
  • 3. J. Lee†, K. J. Schwarz†, D. S. Kim, J. S. Moore, M. C. Jewett, Ribosome-mediated incorporation of long-carbon chain and cyclic amino acids into peptides in vitro, Nat. Commun. 2020, 11, 4304 (†: equally contributed).
  • 4. J. Lee, R. Torres, D. S. Kim, M. Byrom, A. D. Ellington, M. C. Jewett, Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation, Chem. Commun. 2020, 56, 5597. Front cover, Highlighted in Chemistry World.
  • 5. H. Choi, A. P. Hardy, T. M. Leissing, R. Chowdhury, W. Ge, M. Markoulides, J. S. Scotti, H. Thorbjornsrud, D. Kang, S. Hong, J. Lee, H. Park, M. A. McDonough, C. J. Schofield, A human protein hydroxylase that accepts D-residues, Communications Chem. 2020, 3, 52.
  • 6. J. Lee†, K. E. Schwieter†, A. M. Watkins, D. S. Kim, H. Yu, K. J. Schwarz, J. Lim, J. Coronado, M. Byrom, E. V. Anslyn, A. D. Ellington, J. S. Moore, M. C. Jewett, Expanding the limits of the second genetic code with ribozymes, Nat. Commun. 2019, 10, 5097 (†: equally contributed).
  • 7. J. Lee, A. J. Boersma, M. A. Boudreau, S. Cheley, O. Daltrop, J. Li, H. Tamagaki, H. Bayley, Semisynthetic nanoreactor for reversible single-molecule covalent chemistry. ACS Nano 2016, 10, 8843 (Highlighted in
  • 8. J. Lee, H. Bayley, Semisynthetic protein nanoreactor for single-molecule chemistry. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 13768 (Highlighted in
  • 9. N. Cho†, B. Hwang†, J. Yoon†, S. Park†, J. Lee†, H. N. Seo, J. Lee, S. Huh, J. Chung, D. Bang, De novo assembly and next-generation sequencing to analyse full-length gene variants from codon-barcoded libraries, Nat. Commun. 2015, 6, 8351 (†: equally contributed).
  • 10. J. S. Scotti, I. K. H. Leung, W. Ge, M. A. Bentley, J. Paps, H. B. Kramer, J. Lee, W. Aik, H. Choi, S. M. Paulsen, L. A. H. Bowman, N. D. Loik, S. Horita, C. Ho, N. J. Kershaw, C. M. Tang, T. D. W. Claridge, G. M. Preston, M. A. McDonough, C. J. Schofield, Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 13331.
  • 11. H. Kim, H. Han, J. Ahn, J. Lee, N. Cho, H. Jang, H. Kim, S. Kwon, D. Bang, ‘Shotgun DNA synthesis’ for the high-throughput construction of large DNA molecules. Nucleic Acids Res. 2012, 40, e140.
  • 12. J. Lee, Y. Kwon, B. L. Pentelute, D. Bang, Use of model peptides reaction for the characterization of a kinetically-controlled ligation. Bioconjugate Chem. 2011, 22, 1645.
  • 13. J. C. Park, J. U. Bang, J. Lee, C. H. Ko, H. Song, Ni@SiO2 yolk-shell nanoreactor catalysts: high temperature stability and recyclability. J. Mater. Chem. 2010, 20, 1239, Front cover.
  • 14. J. Lee, J. C. Park, J. U. Bang, H. Song, Precise tuning of porosity and surface functionality in Au@SiO2 nanoreactors for high catalytic efficiency. Chem. Mater.2008, 20, 5839.
  • 15. J. Lee, J. C. Park, H. Song, A nanoreactor framework of Au@SiO2 yolk-shell structure for catalytic reduction of p-nitrophenol. Adv. Mater.2008, 20, 1523

연구성과 - 특허

  • 1. D. Bang, S. Park, Joongoo Lee, Jeewon Lee, Method for synthesizing gene library using codon combination and mutagenesis, 2012, WO2014092458 A1.
  • 2. M. C. Jewett, J. S. Moore, J. Lee, K. E. Schwieter, K. J. Schwarz, Expanding the chemical substrates for genetic code reprogramming, 2018, WO2020040840A2

연구성과 - 저서

  • 1. J. Lee†, D. S. Kim†, M. C. Jewett, Engineering ribosomes for natural product biosynthesis Comprehensive Natural Products III: Chemistry and Biology, Elsevier (ISBN: 9780081026908)