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2021 June Vol.34 No.2 ISSN 1598-8384

신진과학자

신진과학자 소개

박해민 (Hae-Min Park)

충남대학교 응용화학공학과 E-mail : haemin.park@cnu.ac.kr


[학력]
  • 2002 - 2007

    서울대학교 화학생물공학부, 학사

  • 2007 - 2014

    서울대학교 화학생물공학부, 박사

[경력]
  • 2014 - 2015

    서울대학교 유전공학연구소, 박사후연구원

  • 2015 - 2016

    LG화학 백신개발팀

  • 2016 - 2020

    Northwestern University, 연구원

  • 2020 - 현재

    충남대학교 응용화학공학과, 조교수

[주요 연구 관심 분야 소개]

  • 질량분석 기반의 오믹스 기술 개발
  • 항체 의약품 분리, 정제 및 분석 자동화 플랫폼 개발
  • 단백질 의약품 제조공정 및 품질평가 기술 개발
  • 질병 진단 및 모니터링을 위한 바이오마커 스크리닝

[연구성과 - 주요논문]

  • 1. Park HM, Winton VJ, Drader JJ, Manalili Wheeler S, Lazar GA, Kelleher NL, Liu Y, Tran JC, Compton PD “Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry” Analytical Chemistry 2020 92(2): 2186-2193
  • 2. Park HM, Satta R, Davis RG, Goo YA, LeDuc RD, Fellers RT, Greer JB, Romanova EV, Rubakhin SS, Tai R, Thomas PM, Sweedler JV, Kelleher NL, Patrie SM, Lasek AW “Multidimensional Top-Down Proteomics of Brain Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol” Journal of Proteome Research 2019 18(11): 3999-4012
  • 3. Park HG, Jang KS, Park HM, Song WS, Jeong YY, Ahn DH, Kim SM, Yang YH, Kim YG “MALDI-TOF MS-based total serum protein fingerprinting for liver cancer diagnosis” Analyst 2019 144(7): 2231-2238
  • 4. Song WS*, Park HM*, Ha JM, Shin SG, Park HG, Kim J, Zhang T, Ahn DH, Kim SM, Yang YH, Jeong JH, Theberge AB, Kim BG, Lee JK, Kim YG “Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma” Scientific Reports 2018 8(1): 11088 (*Joint first authors)
  • 5. Hwang CH*, Park HM*, Park HG, Ahn DH, Kim SM, Ko BJ, Kim YH, Yang YH, Kim YG “Quantitative characterization of intact sialylated O-glycans with MALDI-MS for protein biotherapeutics” Korean Journal of Chemical Engineering 2018 35(7): 1462-1467 (*Joint first authors)
  • 6. Davis RG*, Park HM*, Kim K, Greer JB, Fellers RT, LeDuc RD, Romanova EV, Rubakhin SS, Zombeck JA, Wu C, Yau PM, Gao P, van Nispen AJ, Patrie SM, Thomas PM, Sweedler JV, Rhodes JS, Kelleher NL “Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains” Analytical Chemistry 2018 90(6): 3802-3810 (*Joint first authors)
  • 7. Park HM*, Hwang MP*, Kim YW, Kim KJ, Jin JM, Kim YH, Yang YH, Lee KH, Kim YG “Mass spectrometry-based N-linked glycomic profiling as a means for tracking pancreatic cancer metastasis” Carbohydrate Research 2015 413: 5-11 (*Joint first authors)
  • 8. Kim KJ*, Park HM*, Kim YW, Kim YG, Jin JM, Hwan Kim Y, Yang YH, Kyu Lee J, Chung J, Lee SG, Saghatelian A “Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG)” Biotechnology Progress 2015 31(3): 840-8 (*Joint first authors)
  • 9. Jang KS, Park HM, Kim YG, Kim BG, Kim JH “An on-line platform for the analysis of permethylated oligosaccharides using capillary liquid chromatography-electrospray ionization-tandem mass spectrometry” Journal of Nanoscience and Nanotechnology 2015 15(5): 3962-3966
  • 10. Park HM, Kim YW, Kim KJ, Kim YJ, Yang YH, Jin JM, Kim YH, Kim BG, Shim H, Kim YG “Comparative N-linked glycan analysis of wild-type and α1,3-galactosyltransferase gene knock-out pig fibroblasts using mass spectrometry approaches” Molecules and Cells 2015 38(1): 65-74
  • 11. Kang JM*, Park HM*, Kim YW, Kim YH, Varghese S, Seok HK, Kim YG, Kim SH “Control of mesenchymal stem cell phenotype and differentiation by an artificial biofunctional adhesion matrix” European Cells & Materials 2014 25(28): 387-403 (*Joint first authors)
  • 12. Jeong HJ, Park HM, Kim KJ, Kim YW, Bhatia SK, Lee YK, Yang YH, Kim BG, Kim YG “Highly sensitive glycosylation analysis of membrane glycoproteins avoiding polymeric contaminants” Biotechnology and Bioprocess Engineering 2014 19(3): 545-550
  • 13. Rajesh T, Jeon JM, Song E, Park HM, Seo HM, Kim HJ, Yi DH, Kim YH, Choi KY, Kim YG, Park HY, Lee YK, Yang YH “Putative Role of a Streptomyces coelicolor-Derived α-Mannosidase in Deglycosylation and Antibiotic Production” Applied Biochemistry and Biotechnology 2014 172(3): 1639-1651
  • 14. Lee JS, Shin J, Park HM, Kim YG, Kim BG, Oh JW, Cho SW “Liver extracellular matrix providing dual functions of two-dimensional substrate coating and three-dimensional injectable hydrogel platform for liver tissue engineering" Biomacromolecules 2014 15(1): 206-218
  • 15. Ahn JM, Sung HJ, Yoon YH, Kim BG, Yang WS, Lee C, Park HM, Kim BJ, Kim BG, Lee SY, An HJ, Cho JY “Integrated Glycoproteomics Demonstrates Fucosylated Serum Paraoxonase 1 Alternations in Small Cell Lung Cancer” Molecular & Cellular Proteomics 2014 13(1): 30-48
  • 16. Park HM, Park JH, Kim YW, Kim KJ, Jeong HJ, Jang KS, Kim BG, Kim YG “The Xeno-glycomics database (XDB): a relational database of qualitative and quantitative pig glycome repertoire" Bioinformatics 2013 29(22): 2950-2952
  • 17. Jeong HJ, Adhya M, Park HM, Kim YG, Kim BG “Detection of Hanganutziu-Deicher antigens in O-glycans from pig heart tissues by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry” Xenotransplantation 2013 20(6): 407-414
  • 18. Jang KS, Kim YG, Adhya M, Park HM, Kim BG “The Sweets standing at the Borderline between Allo- and Xenotransplantation” Xenotransplantation 2013 20(4): 199-208
  • 19. Park HM, Yang YH, Kim BG, Kim YG “Structural characterization of a-galactosylated O-glycans isolated from miniature pig kidney and endothelial cells” Carbohydrate Research 2013 369(22): 48-53
  • 20. Park HM, Kim BG, Chang D, Malla S, Joo HS, Kim EJ, Park SJ, Sohng JK, Kim PI "Genome-based cryptic gene discovery and functional identification of NRPS siderophore peptide in Streptomyces peucetius" Applied Microbiology and Biotechnology 2013 97(3): 1213-1222