Harvard Medical School, Department of Cell Biology, 방문연구원
2013 ~ 2013.8
서울대학교 농업생명과학연구원, 선임연구원
2013.9 ~ 2014.1
서울대학교 차세대융합기술연구원, 선임연구원
2014.2 ~ 2020.8
한국식품연구원, 선임연구원
2020.9 ~
서울여자대학교 식품공학과, 조교수
주요 연구 관심 분야 소개
근감소증 개선 식품 소재 발굴 연구
Nutrient sensing 신호전달 기전 연구
기술사업화를 위한 식품 소재화 연구
[연구성과 - 주요논문]
Ahn J, Ha TY, Ahn J, Jung CH, Seo HD, Kim MJ, Kim YS, Jang YJ*. Undaria pinnatifida extract feeding increases exercise endurance and skeletal muscle mass by promoting oxidative muscle remodeling in mice. FASEB J. 2020. 34(6):8068-8081
Jang YJ, Ahn J, Son HJ, Jung CH, Ahn J, Ha TY. Hydrangea serrata Tea Enhances Running Endurance and Skeletal Muscle Mass. Mol Nutr Food Res. 2019. 63(17):e1801149
Jang YJ, Son HJ, Kim JS, Jung CH, Ahn J, Hur J, Ha TY. Coffee consumption promotes skeletal muscle hypertrophy and myoblast differentiation. Food & Function. 2018. 9(2):1102-1111.
[전체논문]
1. Jang YJ, Kim JH, Byun S. Modulation of Autophagy for Controlling Immunity. Cells. 2019. 8(2). pii: E138
2. Son HJ*, Jang YJ*, Jung CH, Ahn J, Ha TY. 2,6-Dimethoxy-1,4-benzoquinone Inhibits 3T3-L1 Adipocyte Differentiation via Regulation of AMPK and mTORC1. Planta Med. 2019. 85(3):210-216.
3. Choi WH*, Jang YJ*, Son HJ, Ahn J, Jung CH, Ha TY. Apigenin inhibits sciatic nerve denervation-induced muscle atrophy. Muscle & Nerve. 2018. 58(2):314-318.
4. Jang YJ, Son HJ, Choi YM, Ahn J, Jung CH, Ha TY. Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7. Oncotarget. 2017. 8(45):78300-78311.
5. Jang YJ, Son HJ, Ahn J, Jung CH, Ha T. Coumestrol modulates Akt and Wnt/β-catenin signaling during the attenuation of adipogenesis. Food & Function. 2016. 7(12):4984-4991.
6. Jang YJ, Jung CH, Ahn J, Gwon SY, Ha TY. Shikonin inhibits adipogenic differentiation via regulation of mir-34a-FKBP1B. Biochemical and Biophysical Research Communications. 2015. 467(4):941-7
7. Jang YJ, Kim J, Shim J, Kim CY, Jang JH, Lee KW, Lee HJ. Decaffeinated coffee prevents scopolamine-induced memory impairment in rats. Behavioural Brain Research. 2013. 245:113-9
8. Jang YJ, Kim J, Shim J, Kim J, Byun S, Oak MH, Lee KW, Lee HJ. Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase. Journal of Pharmacology and Experimental Therapeutics. 2011. 337(3):747-54
9. Jang YJ, Kim JE, Kang NJ, Lee KW, Lee HJ. Piceatannol attenuates 4-hydroxynonenal-induced apoptosis of PC12 cells by blocking activation of c-Jun N-terminal kinase. Annals of the New York Academy of Sciences. 2009. 1171:176-82
10. Jang YJ, Kang NJ, Lee KW, Lee HJ. Protective effects of red wine flavonols on 4-hydroxynonenal-induced apoptosis in PC12 cells. Annals of the New York Academy of Sciences. 2009. 1171:170-5.
11. Cho ES*, Jang YJ*, Kang NJ, Hwang MK, Kim YT, Lee KW, Lee HJ. Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. Free Radical Biology & Medicine. 2009. 46(10):1319-27
12. Cho ES*, Jang YJ*, Hwang MK, Kang NJ, Lee KW, Lee HJ. Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2009. 661(1-2):18-24.
13. Lee DH, Park SH, Ahn J, Hong SP, Lee E, Jang YJ, Ha TY, Huh YH, Ha SY, Jeon TI, Jung CH. Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis. Autophagy. 2020. Ahead of print
14. Lee DH, Park SH, Lee E, Seo HD, Ahn J, Jang YJ, Ha TY, Im SS, Jung CH. Withaferin A exerts an anti-obesity effect by increasing energy expenditure through thermogenic gene expression in high-fat diet-fed obese mice. Phytomedicine. 2020. Ahead of print
15. Yoo A, Jang YJ, Ahn J, Jung CH, Seo HD, Ha TY. Chrysanthemi Zawadskii var. Latilobum Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice. Int J Mol Sci. 2020. 17;21(8):2811.
16. Lee DH, Ahn J, Jang YJ, Seo HD, Ha TY, Kim MJ, Huh YH, Jung CH. Withania somnifera Extract Enhances Energy Expenditure via Improving Mitochondrial Function in Adipose Tissue and Skeletal Muscle. Nutrients. 2020. 12(2):431
17. Woo M, Choi HI, Park SH, Ahn J, Jang YJ, Ha TY, Lee DH, Seo HD, Jung CH. The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells. Biochem Biophys Res Commun. 2020. 9;524(3):744-749
18. Park SH, Choi HI, Ahn J, Jang YJ, Ha TY, Seo HD, Kim YS, Lee DH, Jung CH. Autophagy Functions to Prevent Methylglyoxal-Induced Apoptosis in HK-2 Cells. Oxid Med Cell Longev. 2020. 2020:8340695.
19. Shin EJ, Jo S, Choi S, Cho CW, Lim WC, Hong HD, Lim TG, Jang YJ, Jang M, Byun S, Rhee Y. Red Ginseng Improves Exercise Endurance by Promoting Mitochondrial Biogenesis and Myoblast Differentiation. Molecules. 2020. 25(4):865
20. Park SH, Lee DH, Choi HI, Ahn J, Jang YJ, Ha TY, Jung CH. Synergistic lipid-lowering effects of Zingiber mioga and Hippophae rhamnoides extracts. Exp Ther Med. 2020. 20(3):2270-2278.
21. Kim MJ, Lee DH, Ahn J, Jang YJ, Ha TY, Do E, Jung CH. Nutrikinetic study of fermented soybean paste (Cheonggukjang) isoflavones according to the Sasang typology. Nutr Res Pract. 2020. 14(2):102-108
22. Choi HI, Lee DH, Park SH, Jang YJ, Ahn J, Ha TY, Jung CH. Antiobesity effects of the combination of Patrinia scabiosaefolia root and Hippophae rhamnoides leaf extracts. J Food Biochem. 2020. 44(6):e13214
23. Lee DH, Park SH, Huh YH, Jung Kim M, Seo HD, Ha TY, Ahn J, Jang YJ, Jung CH. Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy. Biomed Pharmacother 2020. 125:109950.
24. Kim NH, Ahn J, Choi YM, Son HJ, Choi WH, Cho HJ, Yu JH, Seo JA, Jang YJ, Jung CH, Ha TY. Differential circulating and visceral fat microRNA expression of non-obese and obese subjects. Clin Nutr. 2019. S0261-5614(19)30147-5.
25. Lee JS, Kim YA, Jang YJ, Oh Y, Byun S. Dihydrocapsaicin Inhibits Epithelial Cell Transformation through Targeting Amino Acid Signaling and c-Fos Expression. Nutrients. 2019. 11(6). pii: E1269.
26. Hur J, Kim M, Choi SY, Jang YJ, Ha TY. Isobavachalcone attenuates myotube atrophy induced by TNF-α through muscle atrophy F-box signaling and the nuclear factor erythroid 2-related factor 2 cascade. Phytother Res. 2019. 33(2):403-411.
27. Kim JS, Lee H, Nirmala FS, Jung CH, Jang YJ, Ha TY, Ahn J. Dry-Fermented Soybean Food (Cheonggukjang) Ameliorates Senile Osteoporosis in the Senescence-Accelerated Mouse Prone 6 Model. J Med Food. 2019. 22(10):1047-1057.
28. Lee DH, Ahn J, Jang YJ, Ha TY, Jung CH. Oleic acid-induced defective autolysosome shows impaired lipid degradation. Biochem Biophys Res Commun. 2019. 513(3):553-559.
29. Nirmala FS, Lee H, Kim JS, Jung CH, Ha TY, Jang YJ, Ahn J. Fermentation Improves the Preventive Effect of Soybean Against Bone Loss in Senescence-Accelerated Mouse Prone 6. J Food Sci. 2019. 84(2):349-357.
30. Kim JS, Lee H, Nirmala FS, Jung CH, Kim MJ, Jang YJ, Ha TY, Ahn J. Dihydrodaidzein and 6-hydroxydaidzein mediate the fermentation-induced increase of antiosteoporotic effect of soybeans in ovariectomized mice. FASEB J. 2019. 33(3):3252-3263.
31. Park SH, Lee DH, Kim MJ, Ahn J, Jang YJ, Ha TY, Jung CH. Inula Japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed A High-Fat Diet. Nutrients. 2018. 11(1). pii: E17.
32. Lee DH, Kim MJ, Park SH, Song EJ, Nam YD, Ahn J, Jang YJ, Ha TY, Jung CH. Bioavailability of Isoflavone Metabolites After Korean Fermented Soybean Paste (Doenjang) Ingestion in Estrogen-Deficient Rats. J Food Sci. 2018. 83(8):2212-2221.
33. Kim MJ, Lee DH, Ahn J, Ha TY, Jang YJ, Do E, Jung CH. A Pilot Study on Characteristics of Metabolomics and Lipidomics according to Sasang Constitution. Evid Based Complement Alternat Med. 2018. 2018:9214960
34. Lee DH, Kim MJ, Song EJ, Kim JH, Ahn J, Nam YD, Jang YJ, Ha TY, Jung CH. Nutrikinetic study of genistein metabolites in ovariectomized mice. PLoS One. 2017. 12(10):e0186320
35. Lee DH, Kim MJ, Ahn J, Lee SH, Lee H, Kim JH, Park SH, Jang YJ, Ha TY, Jung CH. Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice. Molecular Nutrition & Food Research. 2017. 61(12)
36. Choi WH, Son HJ, Jang YJ, Ahn J, Jung CH, Ha TY. Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. Molecular Nutrition & Food Research. 2017. 61(12)
37. Ahn J, Jeong J, Lee H, Sung M, Jung CH, Lee H, Hur J, Park JH, Jang YJ, Ha TY. Poly(lactic-co-glycolic acid) Nanoparticles Potentiate the Protective Effect of Curcumin Against Bone Loss in Ovariectomized Rats. Journal of Biomedical Nanotechnology. 2017. 13, 688–698.
38. Kim DH, Kim TK, Kim YB, Sung JM, Jang YJ, Shim JY, Han SG, Choi YS. Effect of the Duck Skin on Quality Characteristics of Duck Hams. Korean J Food Sci Anim Resour. 2017. 37(3):360-367.
39. Jeon H, Kim JH, Lee E, Jang YJ, Son JE, Kwon JY, Lim TG, Kim S, Park JH, Kim JE, Lee KW. Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo. Oncotarget. 2016. 7(41):67223-67234
40. Jeon EJ, Lee DH, Kim YJ, Ahn J, Kim MJ, Hwang JT, Hur J, Kim M, Jang YJ, Ha TY, Seo DH, Lee JS, Sung MJ, Jung CH. Effects of yuja peel extract and its flavanones on osteopenia in ovariectomized rats and osteoblast differentiation. Molecular Nutrition & Food Research. 2016. 60(12):2587-2601.
41. Lee DH, Ahn J, Jang YJ, Ha TY, Jung CH. Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice. Experimental and Therapeutic Medicine. 2016. 12(1):369-376
42. Choi WH, Ahn J, Jung CH, Jang YJ, Ha TY. β-Lapachone Prevents Diet-Induced Obesity by Increasing Energy Expenditure and Stimulating the Browning of White Adipose Tissue via Downregulation of miR-382 Expression. Diabetes. 2016. 65(9):2490-501
43. Byun S, Lee E, Jang YJ, Kim Y, Lee KW. The NADPH oxidase inhibitor apocynin inhibits UVB-induced skin carcinogenesis. Experimental Dermatology. 2016. 25(6):489-91
44. Lee DH, Kim YJ, Kim MJ, Ahn J, Ha TY, Lee SH, Jang YJ, Jung CH. Pharmacokinetics of Tyrosol Metabolites in Rats. Molecules. 2016. 21(1):E128.
45. Lee H, Im SW, Jung CH, Jang YJ, Ha TY, Ahn J. Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling. Biochemical and Biophysical Research Communications. 2016. 469(3):748-52
46. Lee JH, Kim JE, Jang YJ, Lee CC, Lim TG, Jung SK, Lee E, Lim SS, Heo YS, Seo SG, Son JE, Kim JR, Lee CY, Lee HJ, Lee KW. Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. Molecular Carcinogenesis. 2016. 55(5):552-62
47. Kim YJ, Lee DH, Ahn J, Chung WJ, Jang YJ, Seong KS, Moon JH, Ha TY, Jung CH. Pharmacokinetics, Tissue Distribution, and Anti-Lipogenic/Adipogenic Effects of Allyl-Isothiocyanate Metabolites. PLoS One. 2015. 10(8):e0132151
48. Jung CH, Lee DH, Ahn J, Lee H, Choi WH, Jang YJ, Ha TY. γ-Oryzanol Enhances Adipocyte Differentiation and Glucose Uptake. Nutrients. 2015. 7(6):4851-61.
49. Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular Cell. 2013. 49(1):172-85
50. Kim J, Lee S, Shim J, Kim HW, Kim J, Jang YJ, Yang H, Park J, Choi SH, Yoon JH, Lee KW, Lee HJ. Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H₂O₂-induced apoptosis in primary cortical neurons. Neurochemistry International. 2012. 60(5):466-74
51. Kim JE, Son JE, Jang YJ, Lee DE, Kang NJ, Jung SK, Heo YS, Lee KW, Lee HJ. Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase, inhibits tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. Journal of Pharmacology and Experimental Therapeutics. 2011. 338(3):1013-22
52. Koh K, Kim J, Jang YJ, Yoon K, Cha Y, Lee HJ, Kim J. Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells. Journal of Neuroimmunology. 2011. 233(1-2):160-7
53. Kang MK, Kang NJ, Jang YJ, Lee KW, Lee HJ. Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2. Annals of the New York Academy of Sciences. 2009. 1171: 514–520
