Colorectal cancer (CRC) is regarded as one of the most common and deadly forms of cancer. Gut microbiota is vital to retain and promote several functions of intestinal. Although previous researches have shown that some gut microbiota have the abilities to inhibit tumorigenesis and prevent cancer from progressing, they have not yet clearly identified associative mechanisms. This review not only concentrates on the antitumor effects of metabolites produced by gut microbiota, for example, SCFA, ferrichrome, urolithins, equol and conjugated linoleic acids, but also the molecules which constituted the bacterial cell wall have the antitumor effect in the host, including lipopolysaccharide, lipoteichoic acid, β-glucans and peptidoglycan. The aim of our review is to develop a possible therapeutic method, which use the products of gut microbiota metabolism or gut microbiota constituents to help treat or prevent colorectal cancer.
Teaching Assistant, Lecturer, Associate Professor, Department of Microecology, Dalian Medical University
Visiting scholar, Department of Preventive Dentistry Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Holland
Zhejiang University School of Medicine the Second Affiliated Hospital
E-mail : email@example.com
Dalian Medical University
Zhejiang University School of Medicine
Key Laboratory of Organism Microecology and Disease Control，Liaoning Province was approved to establish in November 2009 by Science and Technology Department of Liaoning Province, which formerly was known as microecological research institute in Dalian Medical University. The main research direction is the relationship between normal microbiota and the host, including gut microbiota, respiratory microbiota, urogenital tract microbiota and microecological regulator. We have developed microecological products like Bacillus, Bifidobacteria and Lactobacillus. The laboratory area is 1100 m2 and fixed-asset of experimental equipment is totally more than 5 million RMB.