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2020 December Vol.33 No.4 ISSN 1598-8384

신진과학자

신진과학자 소개

김 충 섭 (Chung Sub Kim)

성균관대학교 약학대학 E-mail : chungsub.kim@skku.edu

[학 력]

2003. 03 - 2006. 02
인천과학고등학교
2006. 03 - 2010. 02
성균관대학교 약학부, 학사
2010. 03 - 2015. 02
성균관대학교 약학과, 박사 (전공: 천연물화학)

[경 력]

2015. 03 - 2016. 02
성균관대학교 약학연구원, 선임연구원
2016. 03 - 2020. 01
Yale University, Department of Chemistry, 박사후연구원
2020. 03 - 현재
성균관대학교 약학대학, 조교수

주요 연구 관심 분야 소개

마이크로바이옴 유래 생리활성 물질의 분리, 구조결정 및 생합성경로 규명
박테리아의 신호전달물질 및 기전 규명
천연자원으로부터 신약개발 선도물질 발굴

[연구성과 - 논문] (*, co-first; #, corresponding; IF: JCR 2019)

대표논문

Xue, M.*; Kim, C. S.*; Healy, A. R.; Wernke, K. M.; Wang, Z.; Frischling, M. C.; Shine, E. E.; Wang, W.; Herzon, S. B.^#; Crawford, J. M.^# Structure elucidation of colibactin and its DNA cross-links. Science 2019, 365, eaax2685. (IF: 41.845)
Kim, C. S.; Gatisos, A.; Cuesta, S.; Yick, C. L.; Wei, Z.; Chen, H.; Russell, R. M.; Shine, E. E.; Wang, R.; Wyche, T. P.; Piizzi, G.; Flavell, R. A.; Palm, N. W.; Sperandio, V.; Crawford, J. M.^# Characterization of autoinducer-3 structure and biosynthesis in E. coli. ACS Cent. Sci. 2020, 6, 197-206. (IF: 12.685)
Kim, C. S.*; Li, J. –H.*; Barco, B.; Wei, Z.; Park, H. B.; Wang, R.; Wyche, T. P.; Piizzi, G.; Clay, N. K.; Crawford, J. M.^# Cellular stress upregulates indole signaling metabolites in E. coli. Cell Chem. Biol. 2020, 27, 698-707.e7 (IF: 7.739)

전체논문

1. Lee, T. H.; Suh, W. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee. K. R.; Kim, C. S.^# Three new oleanane-type triterpenoidal glycosides from Impatiens balsamina and their biological activity. Plants-Basel 2020, 9, 1083. (IF: 2.762)
2. Park, H. B.*; Wei, Z.*; Oh, J.; Xu, H.; Kim, C. S.; Wang, R.; Wyche, T. P.; Piizzi, G.; Flavell, R. A.; Crawford, J. M.^# Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli. Nat. Microbiol. 2020, in press (IF: 15.540)
3. Vu, N. K.*; Kim, C. S.*; Ha, M, T.; Ngo, Q. -M. T.; Park, S. E.; Kwon, H.; Lee, D.; Choi, J. S.; Kim, J. A.^#; Min, B. S.^# Antioxidant and antidiabetic activities of flavonoid derivatives from the outer skins of Allium cepa L. J. Agric. Food Chem. 2020, 68, 8797-8811. (IF: 4.192)
4. Wernke, K. M.; Xue, M.; Tirla, A.; Kim, C. S.; Crawford, J. M.; Herzon, S. B.^# Structure and bioactivity of colibactin. Bioorg. Med. Chem. Lett. 2020, 30, 127280. (IF: 2.572) - review
5. Kim, C. S.*; Li, J. –H.*; Barco, B.; Wei, Z.; Park, H. B.; Wang, R.; Wyche, T. P.; Piizzi, G.; Clay, N. K.; Crawford, J. M.^# Cellular stress upregulates indole signaling metabolites in E. coli. Cell Chem. Biol. 2020, 27, 698-707.e7 (IF: 7.739)
6. Kim, C. S.; Gatisos, A.; Cuesta, S.; Yick, C. L.; Wei, Z.; Chen, H.; Russell, R. M.; Shine, E. E.; Wang, R.; Wyche, T. P.; Piizzi, G.; Flavell, R. A.; Palm, N. W.; Sperandio, V.; Crawford, J. M.^# Characterization of autoinducer-3 structure and biosynthesis in E. coli. ACS Cent. Sci. 2020, 6, 197-206. (IF: 12.685)
- Highlighted in E. coli. ACS Cent. Sci. (2020, 6, 93-96), Yale News (https://westcampus.yale.edu/news/scientists-zero-endgame-nasty-bacteria?refresh=2), Phys Org News (https://phys.org/news/2020-01-scientists-endgame-nasty-bacteria.html), Health Canal (https://www.healthcanal.com/infections/249907-scientists-zero-in-on-endgame-for-nasty-bacteria.html)
7. Kim, M.; Ha, M. T.; Kim, C. S.; Park, S. E.; Kim, J. A.; Woo, M. H.; Choi, J. S.; Min, B. S.^# Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation. Bioorg. Med. Chem. Lett. 2020, 30, 127049. (IF: 2.572)
8. Xue, M.*; Kim, C. S.*; Healy, A. R.; Wernke, K. M.; Wang, Z.; Frischling, M. C.; Shine, E. E.; Wang, W.; Herzon, S. B.^#; Crawford, J. M.^# Structure elucidation of colibactin and its DNA cross-links. Science 2019, 365, eaax2685. (IF: 41.845)
- Highlighted in Nat. Chem. Biol. (2019, 15, 933), Chemical & Engineering News (https://cen.acs.org/biological-chemistry/microbiome/Researchers-elucidate-colibactin-ctructure/97/i32) and Yale News (https://westcampus.yale.edu/yale-scientists-zero-atomic-driver-tumor-formation)
9. Healy, A. R.; Wernke, K. M.; Kim, C. S.; Lees, N. R.; Crawford, J. M.^#; Herzon, S. B.^# Synthesis and reactivity of precolibactin 886. Nat. Chem. 2019, 11, 890-898. (IF: 21.687)
- Highlighted in Nat. Chem. (2019, 11, 867-869)
10. Lee, S. R.; Lee, D.; Eom, H. J.; Rischer, M.; Ko, Y. –J.; Kang, K. S.; Kim, C. S.; Beemelmanns, C.; Kim, K. H.^# Hybrid polyketides from a Hydractinia-associated Cladosporium sphaerospermum SW67 and their putative biosynthetic origin. Mar. Drugs 2019, 60, 606. (IF: 4.073)
11. Kim, D. H.; Kim, C. S.; Subedi, L.; Kim, S. Y.; Lee, K. R.^# Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities. Tetrahedron Lett. 2019, 60, 151130. (IF: 2.275)
12. Park, K. J.; Kim, C. S.; Khan, Z.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Securinega alkaloids from the twigs of Securinega suffruticosa and their biological activities. J. Nat. Prod. 2019, 82, 1345-1353. (IF: 3.779)
13. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Rare thioglycosides from the roots of Wasabia japonica. J. Nat. Prod. 2018, 81, 2129-2133. (IF: 3.779)
-Highlighted in Nat. Prod. Res. (2018, 35, 1236-1240)
14. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Structural characterization of terpenoids from Abies holophylla using computational and statistical methods and their biological activities. J. Nat. Prod. 2018, 81, 1795-1802. (IF: 3.779)
15. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Two new phenolic glycosides from Sorbus commixta. Chem. Pharm. Bull. 2018, 66, 839-842. (IF: 1.416)
16. Kim, C. S.; Subedi, L.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# A new phenolic compound from Salix glandulosa. Heterocycles 2018, 96, 931-942. (IF: 0.668)
17. Park, K. J.; Kim, D. H.; Kim, C. S.; Oh, J.; Subedi, L.; Son, M. W.; Choi, S. Z.; Kim, S. Y.; Lee, K. R.^# Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis. Tetrahedron Lett. 2018, 59, 4380-4383. (IF: 2.275)
18. Oh, J.; Quan, K. T.; Lee, J. S.; Park. I.; Kim, C. S.; Ferreira, D.;Thuong, P. T.; Kim, Y. H.; Na, M.^# NMR-based investigation of hydrogen bonding in a dihydroanthracen-1(4H)one from Rubia philippinensis and its soluble epoxide hydrolase inhibitory potential. J. Nat. Prod. 2018, 81, 2429-2435. (IF: 3.779)
19. Kim, C. S.; Subedi, L.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Bioactive triterpenoids from the twigs of Chaenomeles sinensis. J. Nat. Prod. 2017, 80, 1134-1140. (IF: 3.779)
20. Kim, C. S.; Bae, M.; Oh, J.; Subedi, L.; Suh, W. S.; Choi, S. Z.; Son, M. W.; Kim, S. Y.; Choi, S. U.; Oh, D.–C.; Lee, K. R.^# Anti-neurodegenerative biflavonoid glycosides from impatiens balsamina. J. Nat. Prod. 2017, 80, 471-478. (IF: 3.779)
21. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Holophyllane A: A triterpenoid possessing an unprecedented B-nor-3,4-seco-17,14-friedo-lanostane architecture from Abies holophylla. Sci. Rep. 2017, 7, 43646. (IF: 3.998)
22. Kim, C. S.; Oh, J.; Suh. W. S.; Jang, S. W.; Subedi, L.; Kim, S. Y.; Lee, K. R.^# Investigation of chemical constituents from Spiraea prunifolia var, simpliciflora and their biological activities. Phytochem. Lett. 2017, 22, 255-260. (IF: 1.459)
23. Triparthi, P.*; Shine, E. E.*; Healy, A. R.; Kim, C. S.; Herzon, S. B.; Bruner, S. D.^#; Crawford, J. M.^# ClbS is a cyclopropane hydrolase that confers colibactin resistance. J. Am. Chem. Soc. 2017, 139, 17719-17722. (IF: 14.612)
- Highlighted in Nat. Chem. Biol. 2018, 14, 1. and J. Am. Chem. Soc. 2017, 139, 18123.
24. Suh, W. S.; Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Iridoid glycosides from the twigs of Sambucus williamsii var. coreana and their biological activities. J. Nat. Prod. 2017, 80, 2502-2508. (IF: 3.779)
25. Nguyen, Q. T.*; Lee, D.–H.*; Oh, J.*; Kim, C. S.; Heo, K.–S.; Myung, C.–S.^#; Na, M.^# Inhibition of proliferation of vascular smooth muscle cells by cucurbitanes from Momordica charantia. J. Nat. Prod. 2017, 80, 2018-2025. (IF: 3.779)
26. Lim, S. Y.*; Subedi, L.*; Shin, D.; Kim, C. S.; Lee, K. R.; Kim, S. Y.^# A new neolignan derivative, balanophonin isolated from Firmiana simplex delays the progress of neuronal cell death by inhibiting microglial activation. Biomol. Ther. 2017, 25, 519-527. (IF: 3.470)
27. Kim, C. S.; Subedi, L.; Kwon, O. W.; Park, H. B.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.^# Wasabisides A-E, lignan glycosides from the roots of Wasabia japonica. J. Nat. Prod. 2016, 79, 2652-2657. (IF: 3.779)
28. Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.^# Diterpenes from the trunk of Abies holophylla and their potential neuroprotective and anti-inflammatory activities. J. Nat. Prod. 2016, 79, 387-394. (IF: 3.779)
29. Kim, C. S.; Suh. W. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Neuroprotective fatty acids from the stem bark of Sorbus commixta. Lipids 2016, 51, 989-995. (IF: 1.919)
30. Kim, C. S.; Subedi, L.; Kwon, O. K.; Kim, S. Y.; Yeo, E. –J.; Choi, S. U.; Lee, K. R.^# Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis. Bioorg. Med. Chem. Lett. 2016, 26, 351-354. (IF: 2.572)
31. Kwon, O. K.; Kim, C. S.; Suh, W. S.; Park, K. J.; Cha, J. M.; Choi, S. U.; Kwon, H. C.; Lee, K. R.^# Phenolic compounds from the twigs of Corylopsis coreana uyeki and their cytotoxic activity. Kor. J. Pharmacogn. 2016, 47, 1-6.
32. Suh, W. S.; Lee, S. R.; Kim, C. S.; Moon, E.; Kim, S. Y.; Choi, S. U.; Kang, K. S.; Lee, K. R.; Kim,K. H.^# A new monoacylglycerol from the fruiting bodies of Gymnopilus spectabilis. J. Chem. Res. 2016, 40, 156-159. (IF: 0.593)
33. Son, D.; Kim, C. S.; Lee, K. R.; Park, H.–J.^# Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay. Bioorg. Med. Chem. Lett. 2016, 26, 2365-2369. (IF: 2.572)
34. Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.^# Lignan glycosides from the twigs of Chaenomeles sinensis and their biological activities. J. Nat. Prod. 2015, 78, 1174-1178. (IF: 3.779)
35. Kim, C. S.; Moon, E.; Choi, S. U.; Kim, S. Y.; Lee, K. L.; Kim, K. H.^# Cytotoxic and anti-inflammatory disulfide compounds from the fruiting bodies of Boletus pseudocalopus. J. Antibiot. 2015, 68, 414-416. (IF: 2.668)
36. Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Choi, S. Z.; Son, M. W.; Kim, K. H.; Lee, K. R.^# Two new phenolic compounds from the white flower of Impatiens balsamina. Phytochem. Lett. 2015, 14, 215-220. (IF: 1.459)
37. Kim, C. S.; Subedi, L.; Park, K. J.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.^# Salicin derivatives from Salix glandulosa and their biological activities. Fitoterapia, 2015, 106, 147-152. (IF: 2.527)
38. Kim, K. H.; Kim, C. S.; Park, Y. J.; Moon, E.; Choi, S. U.; Lee, J. H.; Kim, S. Y.; Lee, K. R.^# Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus. Bioorg. Med. Chem. Lett. 2015, 25, 96-99. (IF: 2.572)
39. Kim, K. H.; Kang, H. R.; Eom, H. J.; Kim, C. S.; Choi, S. U.; Lee, K. R.^# A new aliphatic alcohol and cytotoxic chemical constituents from Acorus gramineus Rhizomes. Biosci. Biotechnol. Biochem. 2015, 79, 1402-1405. (IF: 1.516)
40. Jang, S. W.; Suh, W. S.; Kim, C. S.; Kim, K. H.; Lee, K. R.^# A new phenolic glycoside from Spiraea prunifolia var. simpliciflora twigs. Arch. Pharm. Res. 2015, 38, 1943-1951. (IF: 2.934)
41. Kim, K. H.; Moon, E.; Cha, J. M.; Lee, S.; Yu, J. S.; Kim, C. S.; Kim, S. Y.; Choi, S. U.; Lee, K. R.^# Antineuroinflammatory and antiproliferative activities of constituents from Tilia amurensis. Chem. Pharm. Bull. 2015, 63, 837-842. (IF: 1.416)
42. Roh, H. J.; Noh, H. J.; Kim, C. S.; Kim, K. H.; Hong, C. Y.; Lee, K. R.^# Phenolic compounds from the leaves of Stewartia pseudocamellia Maxim. and their whitening activities. Biomol. Ther. 2015, 23, 283-289. (IF: 3.470)
43. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Kim, J. Y.; Han, J. Y.; Choi, S. I.; Choi, J. G.; Kim, K. H.; Lee, K. R.^# Phenolic Glycosides from the Twigs of Salix glandulosa. J Nat. Prod. 2014, 77, 1955-1961. (IF: 3.779)
44. Kim, C. S.; Shin, B.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Oh, D. C.; Kim, K. H.; Lee, K. R.^# Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla. Tetrahedron Lett. 2014, 55, 6504-6507. (IF: 2.275)
45. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.^# Five new oxylipins from Chaenomeles sinensis. Lipids 2014, 49, 1151-1159. (IF: 1.919)
46. Kim, C. S.; Suh, W. S.; Choi, S. U.; Kim, K. H.; Lee, K. R.^# Two new diterpenoids from Thuja orientalis and their cytotoxicity. Bull. Korean Chem. Soc. 2014, 35, 2855-2858. (IF: 0.611)
47. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Kim, K. H.; Lee, K. R.^# A new cyclic triterpene saponin from Phyteuma japonicum. Heterocycles 2014, 89, 1913-1922. (IF: 0.668)
48. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Lee, K. R.^# Flavonoid glycosides from Hosta longipes, their inhibition on NO production, and nerve growth factor inductive effects. J. Braz. Chem. Soc. 2014, 25, 907-912. (IF: 1.335)
49. Kim, C. S.; Kim, K. H.; Lee, K. R.^# Phytochemical constituents of the leaves of Hosta longipes. Nat. Prod. Sci. 2014, 20, 86-90.
50. Cho, H. K.; Kim, C. S.; Woo, K. W.; Lee, K. R.^# A new triterpene saponin from the tubers of Stachys sieboldii. Bull. Korean Chem. Soc. 2014, 35, 1553-1555. (IF: 0.611)
51. Cho, H. K.; Kim, C. S.; Suh, W. S.; Kim, K. H.; Lee, K. R.^# Two new triterpene saponins from the tubers of Stachys sieboldii. Heterocycles 2014, 89, 2619-2626. (IF: 0.668)
52. Kim, C. S.; Kim, S. Y.; Moon, E.; Lee, M. K.; Lee, K. R.^# Steroidal constituents from the leaves of Hosta longipes and their inhibitory effects on nitric oxide production. Bioorg. Med. Chem. Lett. 2013, 23, 1771-1775. (IF: 2.572)
53. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Lee, K. R.^# Bioactive lignans from the trunk of Abies holophylla. J. Nat. Prod. 2013, 76, 2131-2135. (IF: 3.779)
54. Kim, C. S.; Oh, J. Y.; Choi, S. U.; Lee, K. R.^# Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity. Carbohyd. Res. 2013, 381, 1-5. (IF: 1.841)
55. Kim, K. H.; Moon, S. R.; Kim, C. S.; Woo, K. W.; Choi, S. U.; Lee, K. R.^# Lignan glucosides from Sinomenium acutum rhizomes. Biosci. Biotechnol. Biochem. 2013, 77, 2144-2147. (IF: 1.516)
56. Lee, S. Y.; Woo, K. W.; Kim, C. S.; Lee, D. U.; Lee, K. R.^# New lignans from the aerial parts of Rudbeckia laciniata. Helv. Chim. Acta 2013, 96, 320-325. (IF: 2.309)
57. Oh, J. Y.; Kim, C. S.; Lee, K. R.^# C21 Steroidal glycosides from the root of Cynanchum paniculatum. Bull. Korean Chem. Soc. 2013, 34, 637-640. (IF: 0.611)
58. Kim, C. S.; Choi, S. U.; Lee, K. R.^# Three new diterpenoids from the leaves of Thuja orientalis. Planta Med. 2012, 78, 485-487. (IF: 2.687)
59. Kim, K. H.; Choi, S. U.; Kim, C. S.; Lee, K. R.^# Cytotoxic steroids from the trunk of Berberis koreana. Biosci. Biotechnol. Biochem. 2012, 76, 825-827. (IF: 1.516)

[연구성과 - 특허]

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