신진과학자 소개

주요 연구 관심 분야 소개

• 바이오나노기술 융합형 신소재 개발
• 바이오나노소재의 의약전달체 메커니즘 연구
• 생체 분자 모사를 통한 기능성 헬스케어 소재 개발
• 줄기세포 신호 전달 체계 조절을 통한 조직 재생 유도 연구
• 비침습성 세포 신호 검출을 위한 바이오센서 개발

연구성과 - 논문

*First Author, ^†Corresponding Author

• 1. J.M. Lee*, W.S. Kang*, K.G. Lee*, H.-Y. Cho, B. Conley, C.D. Ahrberg, J.H. Lim, S.J. Mo, S.G. Mun, E.-J. Kim, J.-W. Choi, K.-B. Lee†, S.J. Lee†, B.G. Chung†, “Combinatorial biophysical cue sensor array for controlling neural stem cell fate”, Biosensors and Bioelectronics 2020, 156, 112125 (IF = 9.518, Top 1.19%)
• 2. S.-N. Lee*, J.-H. Choi*, H.-Y. Cho†, J.-W. Choi†, “Metallic Nanoparticles-based Optical Cell chip for Nondestructive Monitoring of Intra/Extracellular Signals”, Pharmaceutics 2020, 12(1), 50 (IF = 4.773, Top 9.74%)
• 3. A. Patel, M.R.N. Lima, H.-Y. Cho, K.-B. Lee, N.S. Murthy†, J. Kohn†, “Disassembly of Nanospheres with a PEG Shell Upon Adsorption onto PEGylated Substrates”, Langmuir 2020, 36(1), 232-241 (IF = 3.683)
• 4. S. Wang*, L. Yang*, H.-Y. Cho, ST.D. Cheung, H. Zhang, Q. Zhang†, K.-B. Lee†, “Programmed Degradation of a Hierarchical Nanoparticles with Redox and Light Responsivity for Self-activated Photo-Chemical Enhanced Chemodynamic Therapy”, Biomaterials 2019, 224, 199498 (IF = 10.273, Top 3.13%)
• 5. J.-H. Lee*, J.-H. Choi*, ST.D. Cheung, T. Pongkulapa, L. Yang, H.-Y. Cho, J.-W. Choi†, K.-B. Lee†, “Nondestructive Characterization of Stem Cell Neurogenesis by a Magneto-Plasmonic Nanomaterial-based Exosomal miRNA Detection”, ACS Nano 2019, 13(8), 8793-8803 (IF = 13.903, Top 6.08%)
• 6. M. Koh*, H.-Y. Cho*, C. Yu, S. Choi, K.-B. Lee†, P.G. Schultz†, “Site-specific Incorporation of a Dithiolane Containing Amino Acid into Proteins”, Bioconjugate Chemistry 2019, 30(8), 2102-2105 (IF = 4.349)
• 7. H.-Y. Cho*, A. Mavi*, ST.D. Cheung, N. Pasquale, H. Rabie, J. Han, J.-H. Kim, T.-H. Kim†, J.-W. Choi†, K.-B. Lee†, “Tumor Homing Reactive Oxygen Species Nanoparticle for Enhanced Cancer Therapy”, ACS Applied Materials and Interfaces 2019, 11(27), 23909-23918 (IF = 8.456, Top 9.22%)
• 8. S. Suryaprakash*, Y.-H. Lao*, H.-Y. Cho*, M. Li, H. Y. Ji, D. Shao, H. Hu, C.H. Quek, D. Huang, R.L. Mintz, J.R. Bagó, S.D. Hingtgen, K.-B. Lee, K.W. Leong†, “Engineered Mesenchymal Stem Cell/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy”, Nano Letters 2019, 19, 1701-1705 (IF = 12.279, Top 6.08%)
• 9. J. Jo, J. Yoon, T. Lee, H.-Y. Cho, J.-Y. Lee, J.-W. Choi†, “H2O2 Biosensor Consisted of Hemoglobin-DNA Conjugate on Nanoporous Gold Thin Film Electrode with Electrochemical Signal Enhancement”, Nano Convergence 2019, 6, 1 (IF = 3.324)
• 10. M. Bhamidipati, H.-Y. Cho, K.-B. Lee, L. Fabris†, “SERS-Based Quantification of Biomarker Expression at the Single Cell Level Enabled by Gold Nanostars and Truncated Aptamers”, Bioconjugate Chemistry 2018, 29(9), 2970-2981 (IF = 4.349)
• 11. P.T. Yin*, T. Pongkulapa*, H.-Y. Cho, J. Han, N.J. Pasquale, H. Rabie, J.-H. Kim, J.-W. Choi†, K.-B. Lee†, “Overcoming Chemoresistance in Cancer via Combined MicroRNA Therapeutics with Anticancer Drugs Using Multifunctional Magnetic Core-Shell Nanoparticles”, ACS Applied Materials and Interfaces 2018, 10(32), 26954-26963 (IF = 8.456, Top 9.22%)
• 12. J.-H. Lee*, H.-Y. Cho*, H.K. Choi, J.-Y. Lee, J.-W. Choi† “Application of Gold Nanoparticles to Plasmonic Biosensor” International Journal of Molecular Science 2018, 19(7), 2021 (IF = 4.183)
• 13. K.-J. Kim*, H.-Y. Cho*, W. -J. Lee, J.-W. Choi†, “Subtyping of Magnetically Isolated Breast Cancer Cells Using Magnetic Force Microscopy”, Biotechnology Journal 2018, 13(6), 1700625 (IF = 3.543)
• 14. H.-Y. Cho*, M.K. Hossain*, J. -H. Lee, J. Han, H. J. Lee, K.-J. Kim, J.-H. Kim, K. B. Lee†, J.-W. Choi†, “Selective Isolation and Noninvasive Analysis of Circulating Cancer Stem Cells Through Raman Imaging” Biosensors and Bioelectronics 2018, 102, 372-382 (IF = 9.518, Top 1.19%)
• 15. H.-Y. Cho*, T. Lee*, J. Yoon, H. Rabie, Z. Han, K.-B. Lee, W.W. Su†, J.-W. Choi†, “Magnetic Oleosome as a Functional Lipophilic Drug Carrier for Cancer Therapy”, ACS Applied Materials & Interfaces 2018, 10(11), 9301-9309 (IF = 8.456, Top 9.22%)
• 16. J.-H. Choi*, H.-Y. Cho*, J.-W. Choi†, “Microdevice Platform for in vitro Nervous System and Its Disease Model”, Bioengineering 2017, 4(3), 77 (IF = -, SCOPUS listed paper)
• 17. Y. Li, H. Hao, M. Swerdel, H.-Y. Cho, K.-B. Lee, R.P. Hart, Y.L. Lyu, L. Cai†, “Top2b is Involved in the Formation of Outer Segment and Synapse During Late-Stage Photoreceptor Differentiation by Controlling Key Genes of Photoreceptor Transcriptional Regulatory Network”, Journal of Neuroscience Research 2017, 95(10), 1951-1964 (IF = 4.139)
• 18. M.A. Kafi, H.-Y. Cho, J.-W. Choi†, “Engineered Peptide-based Nanobiomaterials for Electrochemical Cell Chip”, Nano Convergence 2016, 3, 17 (IF = 3.324)
• 19. M.K. Hossain, H.-Y. Cho, J.-W. Choi†, "Gold Nanosphere-Deposited Substrate for Distinguishing of Breast Cancer Subtypes Using Surface-Enhanced Raman Spectroscopy", Journal of Nanoscience and Nanotechnology 2016, 16(6), 6299-6303 (IF = 1.093)
• 20. M.K. Hossain*, H.-Y. Cho*, K.-J. Kim, J.-W. Choi†, "In situ Monitoring of Doxorubicin Release from Biohybrid Nanoparticles Modified with Antibody and Cell-Penetrating Peptides in Breast Cancer Cells Using Surface-Enhanced Raman Spectroscopy", Biosensors and Bioelectronics 2015, 71, 300-305 (IF = 9.518, Top 1.19%)
• 21. M.A. Kafi, H.-Y. Cho, J.-W. Choi†, “Neural Cell Chip Based Electrochemical Detection of Nanotoxicity", Nanomaterials 2015, 5, 1181-1199 (IF = 4.034) [LINK]
• 22. M.K. Hossain, H.-Y. Cho, K.-J. Kim, J.-W. Choi†, “Silver Nanostar Patterned Substrate for Label-Free Characterization of Breast Cancer Cells Based on Surface-Enhanced Raman Spectroscopy”, Science of Advanced Materials 2014, 6, 2491-2495 (IF = 1.158)
• 23. H.-J. Shin, H.-Y. Cho, S.K. Kim, H.D. Jang, J.-W. Choi†, “Au-Crumpled Graphene Modified Electrode to Detect Neurotransmitters Based on Spectroelectrochemical Method”, Science of Advanced Materials 2014, 6, 2577-2581 (IF = 1.158)
• 24. T.-H. Kim, H.-Y. Cho, K.-B. Lee, S.U. Kim, J.-W. Choi†, “Electrically Controlled Delivery of Cargo into Single Human Neural Stem Cell”, ACS Applied Materials & Interfaces 2014, 6 (23), 20709-20716 (IF = 8.456, Top 9.22%)
• 25. W.A. El-Said, H.-Y. Cho, C.-H. Yea, J.-W. Choi†, “Synthesis of Metal Nanoparticles Inside Living Human Cells Based on the Intracellular Formation Process”, Advanced Materials 2014, 26(6), 910-918 (IF = 25.809, Top 1.35%)
• 26. E.-B. Ko, H.-Y. Cho, T.-H. Kim, C.-H. Yea, J.-W. Choi†, “Cell Chip with a Thiolated Chitosan Self-assembled Monolayer to Detect the Effects of Anticancer Drugs on Breast Normal and Cancer Cells”, Colloids and Surface B: Biointerfaces 2013, 112, 387-392 (IF = 3.973)
• 27. H.J. Lee*, H.-Y. Cho*, J.H. Oh, K. Namkoong, J.G. Lee, J.-M. Park, S.S. Lee, N. Huh†, J.-W. Choi†, “Simultaneous Capture and in situ Analysis of Circulating Tumor Cells Using Multiple Hybrid Nanoparticles”, Biosensors and Bioelectronics 2013, 47, 508–514 (IF = 9.518, Top 1.19%)
• 28. H.-Y. Cho, T.-H. Kim, E.-B Ko, J.-W. Choi†, "Fabrication of Carbon Nanotubes/RGD Peptide Composites to Enhance Electrochemical Performance of Cell Chip", Journal of Biomedical Nanotechnology 2013, 9(8), 1398-1402 (IF = 5.068, JCR2017)
• 29. H.-Y. Cho, T.-H. Kim, S.U. Kim, J.-W. Choi†, “Fabrication of Stem Cell Chip with Peptide Nanopatterned Layer to Detect Cytotoxicity of Environmental Toxicants”, Journal of Nanoscience and Nanotechnology 2012, 12, 834-839 (IF = 1.093)

연구성과 - 특허

• 1. 표면 증강 라만 산란 방법(SERS)을 이용하여 순환 종양세포 및 순환 종양 줄기유사세포를 검출하는 방법 및 이를 이용한 시스템, 최정우, 조현열, 칼리드 호세인, 10-1692052 (2016.12.27)
• 2. SERS-기반 세포내 miRNA 검출용 조성물, 최정우, 칼리드 호세인, 조현열, 김경준, 10-1741816 (2017.05.24)
• 3. 자기적-전기화학적 검출기술을 이용한 암세포의 표현형 동정방법, 최정우, 김경준, 이원준, 조현열, 10-1929625 (2018.12.10)