신진과학자 소개

주요 연구 관심 분야 소개

• 유용 약물 생산 미생물 분리와 동정, 생물 화학적 연구를 통한 생리활성 물질 탐색
• 미생물의 생유기화학적 생합성 유도를 통한 신약후보물질 개발
• 휴면 생합성 유전자 군 (silent biosynthetic gene cluster) 활성화 방법론 개발
• 미생물 유래 약물 생산에 관여하는 신호전달 화합물 및 생유기화학적 기전 연구
• 천연물의 유기합성적 유도체화를 통한 약화학적 구조-활성 상관관계 연구
• 크로마토그래피법에 의한 유기화합물의 분리, 정제
• 고급 유기분광학과 비대칭 유도체화, 분자 모델링에 의한 유기화합물 구조 결정
• 저분자물질 구조결정을 위한 화학적 분석방법 개발

연구성과 - 논문

• 1. Park, JD*.; Moon, K.*; Miller, C.; Rose, J.; Xu, F.; Ebmeier, CC.; Jacobsen, JR.; Mao, D.; Old, WM.; DeShazer, D.; Seyedsayamdost, MR. Thailandenes, Cryptic Polyene Natural Products Isolated from Burkholderia thailandensis Using Phenotype-Guided Transposon Mutagenesis ACS Chemical Biology 2020 doi: 10.1021/acschembio.9b00883 (Impact factor: 4.374) (*Denotes equal contribution)
• 2. Moon, K.; Xu, F.; Seyedsayamdost, M.R. Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered via Bioactivity‐Coupled HiTES Angewandte Chemie 2019, 58, 5973-5977. (Impact factor: 12.257)
• 3. Moon, K.; Xu, F.; Zhang, C.; Seyedsayamdost, M.R. Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria ACS Chemical Biology 2019, 14, 767-774. (Impact factor: 4.374)
• 4. Shin, Y.H.; Beom, J.Y.; Chung, B.; Shin, Y.; Byun, W.S.; Moon, K.; Bae, M.; Lee, S.K.; Oh, K.B.; Shin, J.; Yoon, Y.J.; Oh, D.-C. Bombyxamycins A and B, Cytotoxic Macrocyclic Lactams from an Intestinal Bacterium of the Silkworm Bombyx mori Organic Letters 2019, 21, 1804-1808. (Impact factor: 6.555)
• 5. Xu, F.; Wu, Y.; Zhang, C.; Davis, K.M.; Moon, K.; Bushin, L.B.; Seyedsayamdost, M.R. A genetics-free method for high-throughput discovery of cryptic microbial metabolites Nature Chemical Biology 2019, 15, 161-168. (Impact factor: 12.154)
• 6. Shin, D.; Byun, W.S.; Moon, K.; Kwon, Y.;, Bae, M.; Um, S.:;Lee, S.K.; Oh, D.-C. Coculture of Marine Streptomyces sp. With Bacillus sp. Produces a New Piperazic Acid-Bearing Cyclic Peptide Frontiers in Chemistry 2018, 6, 498. (Impact factor: 3.782)
• 7. Xu, F.; Nazari, B.*; Moon, K.*; Bushin L.B.; Seyedsayamdost M.R. Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens Journal of the American Chemical Society 2017, 139, 9203–9212. (Impact factor: 14.695) (*Denotes equal contribution)
• 8. Mao, D.; Bushin, L. B.; Moon, K.; Wu, Y.; Seyedsayamdost, M. R. Silencing Biosynthetic Genes: Discovery and Characterization of scmR as a Global Regulator of Secondary Metabolism in Burkholderia thailandensis E264 Proceedings of the National Academy of Sciences of United States of America 2017, 114, 2920–2928. (Impact factor: 9.580)
• 9. Nazari, B.; Forneris, C. C.; Gibson, M. I.; Moon, K.; Schramma, K. R.; Seyedsayamdost, M. R. Nonomuraea sp. ATCC 55076 Harbours the Largest Actinomycete Chromosome to Date and the Kistamicin Biosynthetic Gene Cluster MedChemCommun 2017, 8, 780–788. (Impact factor: 2.394)
• 10. Human, Z. R. *; Moon, K. *; Bae, M.; de Beer, Z. W.; Cha, S.; Wingfield, M. J.; Slippers, B.; Oh, D.-C.; Venter, S. N Antifungal Streptomyces spp. associated with the infructescences of two Protea spp. in South Africa Frontiers in Microbiology 2016, 7, 1657. (Impact factor: 4.259) (*Denotes equal contribution)
• 11. Bae, M.; Moon, K.; Kim, J.; Park, H.-J.; Lee, S. K.; Shin, J.; Oh, D.-C. Mohangic acids A-E, p-aminoacetophenonic acids from a marine mudflat-derived Streptomyces sp. Journal of Natural Product 2016, 79, 332-339. (Impact factor: 4.257)
• 12. Moon, K.; Chung, B.; Shin, Y.; Rheingold, A. L.; Moore, C. E.; Park, S. J.; Park, S.; Lee, S. K.; Oh, K.-B.; Shin, J.; Oh, D.-C. Pentacyclic antibiotics from a tidal mud flat-derived actinomycete Journal of Natural Product 2015, 78, 524–529. (Impact factor: 4.257)
• 13. Bae, M.; Kim H.; Moon, K.; Nam, S.-J.; Shin, J.; Oh, K.-B.; Oh, D.-C. Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting Candida albicans isocitrate lyase Organic Letters 2015, 17, 712–715. (Impact factor: 6.555)
• 14. Moon, K.; Ahn, C.-H.; Shin, Y.; Won, T. H.; Ko, K.; Lee, S. K.; Oh, K.-B.; Shin, J.; Nam, S.-I.; Oh, D.-C. New benzoxazine secondary metabolites from an Arctic actinomycete Marine Drugs 2014, 12, 2526–2538. (Impact factor: 3.732)
• 15. Lee, S.-Y.; Moon, K.; Kim, H.; Shin, J.; Oh, D.-C.; Oh, K.-B. Bahamaolide A from the marine-derived Streptomyces sp. CNQ343 inhibits isocitrate lyase in Candida albicans Bioorganic & Medicinal Chemistry Letters 2014, 24, 4291–4293. (Impact factor: 2.448)
• 16. Moon, K.; Lim C.; Kim, S.; Oh, D.-C. Facile determination of the absolute configurations of a-hydroxy acids by chiral derivatization coupled with liquid chromatography-mass spectrometry analysis Journal of Chromatography A 2013, 1272, 141–144. (Impact factor: 3.858)
• 17. Kim, D.-G.; Moon, K.; Kim, S.-H.; Park, S.-H.; Park, S.; Lee, S. K.; Oh, K.-B.; Shin, J.; Oh, D.-C. Bahamaolides A and B, antifungal polyene polyol macrolides from the marine actinomycete Streptomyces sp. Journal of Natural Products 2012, 75, 959–967. (Impact factor: 4.257)
• 18. Park, S.-H.; Moon, K.; Bang, H.-S.; Kim, S.-H.; Kim, D.-G.; Oh, K.-B.; Shin, J.; Oh, D.-C. Tripartilactam, a cyclobutane-bearing tricyclic lactam from a Streptomyces sp. in a dung beetle’s brood ball Organic Letters 2012, 25, 1258–1261. (Impact factor: 6.555)

연구성과 - 특허

• 1. Seyedsayamdost, Mohammad R.; Xu, Fei.; Moon, Kyuho.; Nazari, Beham. Cryptic metabolites and method for activating silent biosynthetic gene clusters in actinomycete bacteria. 국제특허 [특허번호: WO2018/209249 A2, 등록일자: 2018.11.15]
• 2. 신종헌 이상국 문규호 오동찬 최진성 매크로라이드계 유도체 화합물, 이의 생산 방법 및 용도. 서울대학교 산학협력단 특허출원 [출원번호: 10-2019-0051826, 출원일자: 2019.05.02]
• 3. Seyedsayamdost, Mohammad R.; Moon, Kyuho. Taylorflavins and Cebulantin, cryptic antibiotics with selective antimicrobial activity against gram-negative bacterial pathogens. Princeton University office of technology licensing and intellectual property confidential invention disclosure [2019.11.05]